Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

R. Muhamadejev; M. Petrova; R. Smits; A. Plotniece; K. Pajuste; G. Duburs; E. Liepinsh

doi:10.1039/c8nj00160j

Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

R. Muhamadejev (Corresponding Author), M. Petrova, R. Smits, A. Plotniece, K. Pajuste, G. Duburs, E. Liepinsh

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The use of 1,4-dihydropyridine (DHP) vesicles as drug delivery agents can improve the diffusion of nucleoside and nucleotide prodrugs through the cellular membrane without degradation. Different NMR studies: spin-lattice relaxation in the rotating frame (T₁ρ), saturation transfer double difference (STDD), ¹H NMR chemical shift titration, as well as isothermal titration calorimetry (ITC) experiments, showed that mononucleotides bind to 1,4-DHP vesicles. The influence of the structure of the mononucleotides as well as that of the derivatives of 1,4-DHP on the complexation parameters was studied.

Original language	English
Pages (from-to)	6942-6948
Number of pages	7
Journal	New Journal of Chemistry
Volume	42
Issue number	9
DOIs	https://doi.org/10.1039/c8nj00160j
Publication status	Published - 2018
Externally published	Yes

Field of Science*

1.4 Chemical sciences
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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abstract = "The use of 1,4-dihydropyridine (DHP) vesicles as drug delivery agents can improve the diffusion of nucleoside and nucleotide prodrugs through the cellular membrane without degradation. Different NMR studies: spin-lattice relaxation in the rotating frame (T1ρ), saturation transfer double difference (STDD), 1H NMR chemical shift titration, as well as isothermal titration calorimetry (ITC) experiments, showed that mononucleotides bind to 1,4-DHP vesicles. The influence of the structure of the mononucleotides as well as that of the derivatives of 1,4-DHP on the complexation parameters was studied.",

author = "R. Muhamadejev and M. Petrova and R. Smits and A. Plotniece and K. Pajuste and G. Duburs and E. Liepinsh",

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AU - Muhamadejev, R.

AU - Petrova, M.

AU - Smits, R.

AU - Plotniece, A.

AU - Pajuste, K.

AU - Duburs, G.

AU - Liepinsh, E.

PY - 2018

Y1 - 2018

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AB - The use of 1,4-dihydropyridine (DHP) vesicles as drug delivery agents can improve the diffusion of nucleoside and nucleotide prodrugs through the cellular membrane without degradation. Different NMR studies: spin-lattice relaxation in the rotating frame (T1ρ), saturation transfer double difference (STDD), 1H NMR chemical shift titration, as well as isothermal titration calorimetry (ITC) experiments, showed that mononucleotides bind to 1,4-DHP vesicles. The influence of the structure of the mononucleotides as well as that of the derivatives of 1,4-DHP on the complexation parameters was studied.

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VL - 42

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JF - New Journal of Chemistry

IS - 9

ER -

Study of interactions of mononucleotides with 1,4-dihydropyridine vesicles using NMR and ITC techniques

Abstract

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