Sudden onset orthostatic dysarthria as a presenting symptom of bulbar onset myasthenia gravis: a video case report

Jānis Dāvis Osipovs (Corresponding Author), Eva Šankova, Guntis Karelis, Ziedīte Želve, Elīna Polunosika, Līga Savicka

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Abstract

Myasthenia gravis (MG) is a rare autoimmune neuromuscular disorder that can present with various early clinical symptoms and signs. The diagnosis of MG with bulbar symptom onset can be clinically challenging for clinicians with limited experience with neuromuscular disorders.
This case report presents an elderly patient with an abrupt onset of orthostatic dysarthria, in whom a high level of diagnostic suspicion leads to a short period until confirmation of diagnosis. This clinical case shows symptomatic treatment initiation on the 4th day after the onset of symptoms in a patient with bulbar onset MG. Serologic confirmation of MG was received on the 11th hospitalisation day. This case report contains a short video of the evaluation of orthostatic dysarthria.
Orthostatic dysarthria is a rare presentation symptom for bulbar onset MG. Information on the evaluation of orthostatic dysarthria is sparse. Considering that bulbar onset MG can be a life-threatening condition, we would like to share our positive experience of rapid diagnosis and successful treatment.
Original languageEnglish
Article number100235
Number of pages3
JournalNeuroimmunology Reports
Volume7
DOIs
Publication statusPublished - 1 Jan 2025

Keywords*

  • Myasthenia gravis
  • Orthostatic dysarthria
  • Neostigmine test
  • Acetylcholine receptor antibodies
  • Case report

Field of Science*

  • 3.2 Clinical medicine
  • 3.3 Health sciences

Publication Type*

  • 1.3. Anonymously reviewed scientific article published in a journal with an international editorial board and is available in another indexed database

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