Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis

Matthias Held; Christine Pausch; Doerte Huscher; David Pittrow; Michael Halank; Stephan Beckmann; Stefan Stadler; Khodr Tello; Ekkehard Grünig; Christian Opitz; Marion Delcroix; H Ardeschir Ghofrani; Juergen Behr; Andris Skride; Dirk Skowasch; Anton Vonk-Noordegraaf; Silvia Ulrich; Hans Klose; Stephan Rosenkranz; Karen M Olsson; Marius M Hoeper; Grzegorz Kopec

doi:10.1183/23120541.00230-2025

Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis

Matthias Held
, Christine Pausch
, Doerte Huscher
, David Pittrow
, Michael Halank
, Stephan Beckmann
, Stefan Stadler
, Khodr Tello
, Ekkehard Grünig
, Christian Opitz
, Marion Delcroix
, H Ardeschir Ghofrani
, Juergen Behr
, Andris Skride
, Dirk Skowasch
, Anton Vonk-Noordegraaf
, Silvia Ulrich
, Hans Klose
, Stephan Rosenkranz
, Karen M Olsson

Marius M Hoeper (Corresponding Author), Grzegorz Kopec

Rīga Stradiņš University

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

This analysis from the COMPERA registry suggests that in medically treated patients with CTEPH, the soluble guanylate cyclase stimulator riociguat may confer a survival benefit over other PH medications.

Original language	English
Article number	00230
Journal	ERJ Open Research
Volume	11
Issue number	6
DOIs	https://doi.org/10.1183/23120541.00230-2025
Publication status	Published - Dec 2025

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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10.1183/23120541.00230-2025Licence: CC BY-NC

Survival in patients with chronic thromboembolic pulmonary hypertensionFinal published version, 652 KBLicence: CC BY-NC

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Held, M., Pausch, C., Huscher, D., Pittrow, D., Halank, M., Beckmann, S., Stadler, S., Tello, K., Grünig, E., Opitz, C., Delcroix, M., Ghofrani, H. A., Behr, J., Skride, A., Skowasch, D., Vonk-Noordegraaf, A., Ulrich, S., Klose, H., Rosenkranz, S., ... Kopec, G. (2025). Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis. ERJ Open Research, 11(6), Article 00230. https://doi.org/10.1183/23120541.00230-2025

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title = "Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis",

abstract = "This analysis from the COMPERA registry suggests that in medically treated patients with CTEPH, the soluble guanylate cyclase stimulator riociguat may confer a survival benefit over other PH medications.",

author = "Matthias Held and Christine Pausch and Doerte Huscher and David Pittrow and Michael Halank and Stephan Beckmann and Stefan Stadler and Khodr Tello and Ekkehard Gr{\"u}nig and Christian Opitz and Marion Delcroix and Ghofrani, \{H Ardeschir\} and Juergen Behr and Andris Skride and Dirk Skowasch and Anton Vonk-Noordegraaf and Silvia Ulrich and Hans Klose and Stephan Rosenkranz and Olsson, \{Karen M\} and Hoeper, \{Marius M\} and Grzegorz Kopec",

note = "Copyright {\textcopyright}The authors 2025.",

year = "2025",

month = dec,

doi = "10.1183/23120541.00230-2025",

language = "English",

volume = "11",

journal = "ERJ Open Research",

issn = "2312-0541",

publisher = "European Respiratory Society",

number = "6",

}

Held, M, Pausch, C, Huscher, D, Pittrow, D, Halank, M, Beckmann, S, Stadler, S, Tello, K, Grünig, E, Opitz, C, Delcroix, M, Ghofrani, HA, Behr, J, Skride, A, Skowasch, D, Vonk-Noordegraaf, A, Ulrich, S, Klose, H, Rosenkranz, S, Olsson, KM, Hoeper, MM & Kopec, G 2025, 'Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis', ERJ Open Research, vol. 11, no. 6, 00230. https://doi.org/10.1183/23120541.00230-2025

TY - JOUR

T1 - Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications

T2 - a COMPERA analysis

AU - Held, Matthias

AU - Pausch, Christine

AU - Huscher, Doerte

AU - Pittrow, David

AU - Halank, Michael

AU - Beckmann, Stephan

AU - Stadler, Stefan

AU - Tello, Khodr

AU - Grünig, Ekkehard

AU - Opitz, Christian

AU - Delcroix, Marion

AU - Ghofrani, H Ardeschir

AU - Behr, Juergen

AU - Skride, Andris

AU - Skowasch, Dirk

AU - Vonk-Noordegraaf, Anton

AU - Ulrich, Silvia

AU - Klose, Hans

AU - Rosenkranz, Stephan

AU - Olsson, Karen M

AU - Hoeper, Marius M

AU - Kopec, Grzegorz

PY - 2025/12

Y1 - 2025/12

N2 - This analysis from the COMPERA registry suggests that in medically treated patients with CTEPH, the soluble guanylate cyclase stimulator riociguat may confer a survival benefit over other PH medications.

AB - This analysis from the COMPERA registry suggests that in medically treated patients with CTEPH, the soluble guanylate cyclase stimulator riociguat may confer a survival benefit over other PH medications.

UR - https://pubmed.ncbi.nlm.nih.gov/41367669/

UR - https://www-scopus-com.db.rsu.lv/pages/publications/105029382000?origin=resultslist

U2 - 10.1183/23120541.00230-2025

DO - 10.1183/23120541.00230-2025

M3 - Article

C2 - 41367669

SN - 2312-0541

VL - 11

JO - ERJ Open Research

JF - ERJ Open Research

IS - 6

M1 - 00230

ER -

Survival in patients with chronic thromboembolic pulmonary hypertension treated with riociguat versus other medications: a COMPERA analysis

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