Synthesis and pharmacological activity of silyl isoxazolines 2

V. Dirnens; V. Klusa; J. Skuyins; S. Svirskis; S. Germane; A. Kemme; J. Popelis; E. Lukevics

doi:10.1023/B:SILC.0000047923.82250.32

Synthesis and pharmacological activity of silyl isoxazolines 2

V. Dirnens, V. Klusa, J. Skuyins, S. Svirskis, S. Germane, A. Kemme, J. Popelis, E. Lukevics

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3- tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si-O-Si fragment in the trans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)] pyridinium-chloride have been studied.

Original language	English
Pages (from-to)	11-25
Number of pages	15
Journal	Silicon Chemistry
Volume	2
Issue number	1-2
DOIs	https://doi.org/10.1023/B:SILC.0000047923.82250.32
Publication status	Published - Jan 2003
Externally published	Yes

Keywords*

Allylsilanes
Anti-amnesic activity
Brain monoaminessilicon
Disiloxanes
Isoxazolines
Memory-stimulating action
Nitrile oxide
Silicon
Vinylsilanes

Field of Science*

1.4 Chemical sciences
2.5 Materials engineering
2.6 Medical engineering

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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10.1023/B:SILC.0000047923.82250.32

Cite this

@article{7d7206db0b5b4f4f86ca4c29649fb140,

title = "Synthesis and pharmacological activity of silyl isoxazolines 2",

abstract = "Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3- tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si-O-Si fragment in the trans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)] pyridinium-chloride have been studied.",

keywords = "Allylsilanes, Anti-amnesic activity, Brain monoaminessilicon, Disiloxanes, Isoxazolines, Memory-stimulating action, Nitrile oxide, Silicon, Vinylsilanes",

author = "V. Dirnens and V. Klusa and J. Skuyins and S. Svirskis and S. Germane and A. Kemme and J. Popelis and E. Lukevics",

note = "Funding Information: The authors are grateful to Taiho Latvian Foundation for financial support.",

year = "2003",

month = jan,

doi = "10.1023/B:SILC.0000047923.82250.32",

language = "English",

volume = "2",

pages = "11--25",

journal = "Silicon Chemistry",

issn = "1569-0660",

publisher = "Kluwer Academic Publishers",

number = "1-2",

}

TY - JOUR

T1 - Synthesis and pharmacological activity of silyl isoxazolines 2

AU - Dirnens, V.

AU - Klusa, V.

AU - Skuyins, J.

AU - Svirskis, S.

AU - Germane, S.

AU - Kemme, A.

AU - Popelis, J.

AU - Lukevics, E.

N1 - Funding Information: The authors are grateful to Taiho Latvian Foundation for financial support.

PY - 2003/1

Y1 - 2003/1

N2 - Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3- tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si-O-Si fragment in the trans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)] pyridinium-chloride have been studied.

AB - Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3- tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si-O-Si fragment in the trans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)] pyridinium-chloride have been studied.

KW - Allylsilanes

KW - Anti-amnesic activity

KW - Brain monoaminessilicon

KW - Disiloxanes

KW - Isoxazolines

KW - Memory-stimulating action

KW - Nitrile oxide

KW - Silicon

KW - Vinylsilanes

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U2 - 10.1023/B:SILC.0000047923.82250.32

DO - 10.1023/B:SILC.0000047923.82250.32

M3 - Article

AN - SCOPUS:33846783188

SN - 1569-0660

VL - 2

SP - 11

EP - 25

JO - Silicon Chemistry

JF - Silicon Chemistry

IS - 1-2

ER -

Synthesis and pharmacological activity of silyl isoxazolines 2

Abstract

Keywords*

Field of Science*

Publication Type*

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