Synthesis and pharmacological activity of silyl isoxazolines 2

V. Dirnens, V. Klusa, J. Skuyins, S. Svirskis, S. Germane, A. Kemme, J. Popelis, E. Lukevics

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Silyl isoxazolines have been synthesized by [2+3] cycloaddition reaction of nitrile oxides to vinyl- and allylsilanes. The addition of 3-pyridylnitrile oxide to 1,3-divinyl-1,1,3,3-tetraphenyldisiloxane affords 1,3-bis{5-[3-(3-pyridyl)isoxazolin-2-yl]}-1,1,3,3- tetraphenyldisiloxane; the latter exists as a mixture of trans- and cis-isomers.The bond angle of the Si-O-Si fragment in the trans-isomer equals 180(3)° and in the cis-isomer it is 162(3)°.The pharmacological properties of 4-[3-(5-trimethylsilylisoxazolin-2-yl)] pyridinium-chloride have been studied.

Original languageEnglish
Pages (from-to)11-25
Number of pages15
JournalSilicon Chemistry
Issue number1-2
Publication statusPublished - Jan 2003
Externally publishedYes


  • Allylsilanes
  • Anti-amnesic activity
  • Brain monoaminessilicon
  • Disiloxanes
  • Isoxazolines
  • Memory-stimulating action
  • Nitrile oxide
  • Silicon
  • Vinylsilanes

Field of Science*

  • 1.4 Chemical sciences
  • 2.5 Materials engineering
  • 2.6 Medical engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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