Synthesis of 4 H-Pyran derivatives under solvent-free and grinding conditions

Rufus Smits, Sergey Belyakov, Aiva Plotniece, Gunars Duburs

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Based on X-ray diffraction analysis, we have proved that the recently published results for ethyl 6-amino-5-cyano-4-aryl-1,4-dihydropyridine-3- carboxylate synthesis is in fact an environmentally friendly synthesis of 6-amino-5-cyano-4-aryl-4H-pyran derivatives using a multicomponent room-temperature grinding procedure of ethyl acetoacetate, [(2-aryl)methylene] malononitriles, and ammonium acetate.

Original languageEnglish
Pages (from-to)465-475
Number of pages11
JournalSynthetic Communications
Issue number4
Publication statusPublished - 1 Jan 2013
Externally publishedYes


  • 4 H-pyran derivatives
  • Green synthesis
  • grinding
  • multicomponent reactions
  • solvent-free
  • X-ray diffraction

Field of Science*

  • 1.4 Chemical sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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