New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor® has been developed.
- Electrophilic fluorination
- Fluorine-containing heterocycles
- Homoallyl long-range coupling
Field of Science
- 3.1 Basic medicine
- 1.4 Chemical sciences
- 1.1. Scientific article indexed in Web of Science and/or Scopus database