Abstract
New fluorinated 3,6-dihydropyridines were obtained by the electrophilic fluorination of 1,2-dihydropyridines with Selectfluor®. These 3-fluoro-3,6-dihydropyridines were easily converted to corresponding pyridines by the elimination of hydrogen fluoride under mild conditions. A new approach to the synthesis of methyl 2-(fluoromethyl)-5-nitro-6-arylnicotinates by the fluorination of 3-fluoro-2-methyl-5-nitro-3,6-dihydropyridines or 1,2-dihydropyridines with Selectfluor® has been developed.
Original language | English |
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Article number | 3143 |
Journal | Molecules |
Volume | 25 |
Issue number | 14 |
DOIs | |
Publication status | Published - Jul 2020 |
Externally published | Yes |
Keywords*
- Dihydropyridines
- Electrophilic fluorination
- Fluorine-containing heterocycles
- Homoallyl long-range coupling
- Selectfluor®
Field of Science*
- 3.1 Basic medicine
- 1.4 Chemical sciences
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database