Temporary organ substitution by hemoperfusion through suspension of active donor hepatocytes in a total complex of intensive therapy in patients with acute hepatic insufficiency

Miron S. Margulis, Efim A. Erukhimo, Ludvig A. Andreiman, Ludmila M. Viksna

Research output: Contribution to journalArticlepeer-review

69 Citations (Scopus)

Abstract

The results of intensive therapy and temporary organ substitution by hemoperfusion through a suspension of active hepatocytes in 126 patients suffering from acute hepatic insufficiency (AHD induced by virus B hepatitis, virus non-A, non-13 hepatitis, acute toxic hepatitis, active liver cirrhosis, sepsis leptospirosis long-term subhepatic jaundice are presented in this paper. Hepatic encephalopathia confirmed both clinically and electro-encephalographically was registered in all the patients. The patients were subdivided into two groups: a complex of commonly used curative measures according to the intensive therapy for AHI was applied in Group A (67 patients); in Group B (59 patients), alongside with the above measures, temporary organ substitution by hemoperfusion through a suspension of active porky hepatocytes was also performed. The lethality in Group A made up 59% and that in Group B was 37%.

Original languageEnglish
Pages (from-to)85-94
Number of pages10
JournalResuscitation
Volume18
Issue number1
DOIs
Publication statusPublished - Oct 1989

Keywords

  • Acute hepatic insufficiency
  • Hemoperfusion through hepatocytes
  • Hepatic encephalopathia

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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