Tetrapeptide QDPR is a minimal immunodominant epitope within the preS2 domain of hepatitis B virus

I. Sominskaya, V. Bichko, P. Pushko, A. Dreimane, D. Snikere, P. Pumpens

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

A hepatitis B virus preS2 deletion library with the preS2 sequence fused to the coat protein of the RNA phage fr (fr CP) as a carrier has been constructed and used for the approximate localization of epitope recognized by a panel of murine monoclonal anti-preS2 antibodies. DNA copies of putative preS2 epitopes were synthesized and cloned within the fr CP gene. Tetrapeptide Gln-Asp-Pro-Arg (QDPR) corresponding to the preS (132-135) sequence was found to be the minimal sufficient recognition site for one of the monoclonal antibodies, S26. The closely related tetrapeptide EDPR did not mimic the epitope activity of QDPR.

Original languageEnglish
Pages (from-to)169-172
Number of pages4
JournalImmunology Letters
Volume33
Issue number2
DOIs
Publication statusPublished - Jul 1992
Externally publishedYes

Keywords

  • Anti-preS2 antibody
  • Epitope
  • PreS2 deletion library

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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