TY - JOUR
T1 - The antiviral innate immune response in fish
T2 - Evolution and conservation of the IFN system
AU - Langevin, Christelle
AU - Aleksejeva, Elina
AU - Passoni, Gabriella
AU - Palha, Nuno
AU - Levraud, Jean Pierre
AU - Boudinot, Pierre
N1 - Funding Information:
This article is dedicated to the memory of Pierre de Kinkelin, who pioneered the study of fish IFNs and will be dearly missed after passing away in May 2013. The research leading to these results has received funding from the European Community's Seventh Framework Programme [FP7-PEOPLE-2011-ITN] under grant agreement no. PITN-GA-2011-289209 for the Marie-Curie Initial Training Network FishForPharma. N.P. is endowed with a fellowship from Fundação para a Ciência e a Tecnologia (SFRH/BD/60678/2009). This work was also funded by the ANR grant “Zebraflam” (ANR-10-MIDI-009).
PY - 2013/12/13
Y1 - 2013/12/13
N2 - Innate immunity constitutes the first line of the host defense after pathogen invasion. Viruses trigger the expression of interferons (IFNs). These master antiviral cytokines induce in turn a large number of interferon- stimulated genes, which possess diverse effector and regulatory functions. The IFN system is conserved in all tetrapods as well as in fishes, but not in tunicates or in the lancelet, suggesting that it originated in early vertebrates. Viral diseases are an important concern of fish aquaculture, which is why fish viruses and antiviral responses have been studied mostly in species of commercial value, such as salmonids. More recently, there has been an interest in the use of more tractable model fish species, notably the zebrafish. Progress in genomics now makes it possible to get a relatively complete image of the genes involved in innate antiviral responses in fish. In this review, by comparing the IFN system between teleosts and mammals, we will focus on its evolution in vertebrates.
AB - Innate immunity constitutes the first line of the host defense after pathogen invasion. Viruses trigger the expression of interferons (IFNs). These master antiviral cytokines induce in turn a large number of interferon- stimulated genes, which possess diverse effector and regulatory functions. The IFN system is conserved in all tetrapods as well as in fishes, but not in tunicates or in the lancelet, suggesting that it originated in early vertebrates. Viral diseases are an important concern of fish aquaculture, which is why fish viruses and antiviral responses have been studied mostly in species of commercial value, such as salmonids. More recently, there has been an interest in the use of more tractable model fish species, notably the zebrafish. Progress in genomics now makes it possible to get a relatively complete image of the genes involved in innate antiviral responses in fish. In this review, by comparing the IFN system between teleosts and mammals, we will focus on its evolution in vertebrates.
KW - evolution of immunity
KW - fish immunology
KW - innate antiviral immunity
KW - interferon
KW - virus
UR - http://www.scopus.com/inward/record.url?scp=84887992036&partnerID=8YFLogxK
U2 - 10.1016/j.jmb.2013.09.033
DO - 10.1016/j.jmb.2013.09.033
M3 - Review article
C2 - 24075867
AN - SCOPUS:84887992036
SN - 0022-2836
VL - 425
SP - 4904
EP - 4920
JO - Journal of Molecular Biology
JF - Journal of Molecular Biology
IS - 24
ER -