Abstract
Objective: The Increased risk of endometrial cancer in postmenopausal
women treated with tamoxifen for breast carcinoma is well documented,
however the coexistence of synchronous BRCA-1 positive breast invasive lobular carcinoma with BRCA-1 negative endometrial endometrioid
adenocarcinoma is not well established. The aim of our study was to
describe a rare case of synchronous BRCA-1 positive breast invasive
lobular carcinoma with metastatic spread in ovary and BRCA-1 negative
endometrial endometrioid adenocarcinoma.
Method: Seventy-four years old postmenopausal patient was enrolled in
the study. Patients underwent clinical examination (US, CT, MRI) and
core needle biopsy and endometrial curettage. The tissue samples were
stained with haematoxylin-eosin and immunohistochemically with ER,
PR, Ki-67, E-cadherin, BRCA-1, CD-56, mammoglobin and calretinin.
Furthermore, the BRCA-1 mutation in breast and endometrial tissue was
assessed by RT-PCR.
Results: The histopathological examination confirmed the invasive lobular carcinoma in the breast with metastasis in the ovary. The tumour was
ER, PR positive, Her-2-negative. Both primary and metastatic tumour
exhibited BRCA-1 mutations. In addition, the endometrial endometrioid
adenocarcinoma was observed. The tumour was ER, PR-positive, but
BRCA-1 negative by immunohistochemistry and did not showed BRCA1 mutations by PCR.
Conclusion: Our study reported the rare case of synchronous BRCA-1
positive lobular carcinoma an
women treated with tamoxifen for breast carcinoma is well documented,
however the coexistence of synchronous BRCA-1 positive breast invasive lobular carcinoma with BRCA-1 negative endometrial endometrioid
adenocarcinoma is not well established. The aim of our study was to
describe a rare case of synchronous BRCA-1 positive breast invasive
lobular carcinoma with metastatic spread in ovary and BRCA-1 negative
endometrial endometrioid adenocarcinoma.
Method: Seventy-four years old postmenopausal patient was enrolled in
the study. Patients underwent clinical examination (US, CT, MRI) and
core needle biopsy and endometrial curettage. The tissue samples were
stained with haematoxylin-eosin and immunohistochemically with ER,
PR, Ki-67, E-cadherin, BRCA-1, CD-56, mammoglobin and calretinin.
Furthermore, the BRCA-1 mutation in breast and endometrial tissue was
assessed by RT-PCR.
Results: The histopathological examination confirmed the invasive lobular carcinoma in the breast with metastasis in the ovary. The tumour was
ER, PR positive, Her-2-negative. Both primary and metastatic tumour
exhibited BRCA-1 mutations. In addition, the endometrial endometrioid
adenocarcinoma was observed. The tumour was ER, PR-positive, but
BRCA-1 negative by immunohistochemistry and did not showed BRCA1 mutations by PCR.
Conclusion: Our study reported the rare case of synchronous BRCA-1
positive lobular carcinoma an
| Original language | English |
|---|---|
| Article number | PS-03-164 |
| Pages (from-to) | S124-S124 |
| Journal | Virchows Archiv |
| Volume | 465 |
| Issue number | Suppl.1 |
| DOIs | |
| Publication status | Published - Aug 2014 |
| Event | 26th European Congress of Pathology: Understanding Disease - London, United Kingdom Duration: 30 Aug 2014 → 3 Sept 2014 Conference number: 26 https://www.esp-pathology.org/events-newsroom/events/congresses-events/26th-european-congress-of-pathology-understanding-disease.html https://www.pathsoc.org/_userfiles/pages/files/meetings/archive/ECP2014_Final-Programme_0801-3.pdf |
Field of Science*
- 3.2 Clinical medicine
Publication Type*
- 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database
