The correlation between abnormal uterine artery flow in the first trimester and genetic thrombophilic alteration: a prospective case-controlled pilot study

Natalija Vedmedovska (Coresponding Author), Diana Bokucava, Anda Kivite-Urtane, Vita Rovite, Liene Zake-Nikitina, Janis Klovins, Violeta Fodina, Gilbert G.G. Donders

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction. Evaluation of the first trimester uterine artery flow can predict the development of obstetrical complications. A genotype, making women prone to microthrombi. constitutes the main known susceptibility factor for anomalous development of placenta. Our aim was to study whether polymorphisms of 10 genes leading to blood clotting abnormalities are related to abnormal uterine artery blood flow in the first trimester, and may predict placenta-related diseases. Material and methods. In primary analyses we included 19 singleton pregnancies with abnormal blood flow in the uterine arteries during the first trimester of gestation, and 24 matched control with normal flow patterns. All patients were genotyped for sequence variations in F5, F2, F11, MTHFR, SERPINE-1, CYP4V2, SELE, GP6, angiotensinogen (AGT) and fibrinogen gamma (FGG) genes and followed up until delivery. Results. There were no differences between groups regarding selected sequence variations in any of these genes. The co-occurrence of several polymorphisms in the same patient was also not related to the blood flow patterns in the uterine arteries. Conclusions. Although we found certain trends of genetic polymorphisms being related to preeclampsia and fetal growth, we failed to find an association between clotting gene polymorphisms, single or in combination, with the abnormal uterine flow in the first trimester.

Original languageEnglish
Article number654
JournalDiagnostics
Volume10
Issue number9
DOIs
Publication statusPublished - Sep 2020

Keywords

  • Abnormal uterine artery flow
  • Genetic polymorphisms

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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