The effect of ACTH on the plasma level of non-esterified fatty acids in healthy subjects and in diabetic patients

K. K. Heidemann, T. H. Freimane

Research output: Contribution to journalArticlepeer-review

Abstract

Following an intramuscular injection of ACTH to a group of healthy subjects a decrease was observed in the level of non-esterified fatty acids of the plasma, replaced by an increase in their concentration, whereas in a group of diabetes patients only a stage of decrease was observed under identical conditions. The most marked decrease in the concentration of non-esterified fatty acids in the plasma was noted in cases with a higher initial level. No quantitative relationship could be established between the decrease in the concentration of non-esterified fatty acids in the plasma was noted in cases with a higher initial level. No quantitative relationship could be established between the decrease in the concentration of non-esterified fatty acids and the increase in the amount of free 11-hydroxycorticosteroids of the plasma following an ACTH injection. The results of observations evidence the dependence of the ACTH administration effect on the initial condition of the organism, and agree with the hypothesis of a direct, extraadrenal mechanism of ACTH action on the level of non-esterified fatty acids of the plasma.

Original languageEnglish
Pages (from-to)516-518
Number of pages3
JournalBulletin of Experimental Biology and Medicine
Volume59
Issue number5
DOIs
Publication statusPublished - May 1965
Externally publishedYes

Field of Science

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'The effect of ACTH on the plasma level of non-esterified fatty acids in healthy subjects and in diabetic patients'. Together they form a unique fingerprint.

Cite this