The effect of BMP-2 and VEGF loading of gelatin-pectin-BCP scaffolds to enhance osteoblast proliferation

Jhaleh Amirian, Nguyen Thuy Ba Linh, Young Ki Min, Byong Taek Lee (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


A composite scaffold of gelatine (Gel)-pectin (Pec)-biphasic calcium phosphate (BCP) was successfully fabricated. Growth factors such as bone morphogenetic protein-2 (BMP-2) and vascular endothelial growth factor (VEGF) were loaded into the Gel-Pec-BCP hydrogel scaffolds by freeze-drying. The surface morphology was investigated by scanning electron microscopy, and BCP dispersion in the hydrogel scaffolds was measured by energy dispersive and X-ray diffraction spectroscopy. The results obtained from Fourier transform infrared spectroscopy and quantitative measurements showed successfully loading of BMP-2 and VEGF into the Gel-Pec-BCP hydrogel scaffolds. In addition MC3T3-E1 preosteoblasts were cultivated on the three types of scaffolds to investigate the effects of BMP-2 and VEGF on cell viability and proliferation. The Gel-Pec-BCP scaffolds loaded with VEGF and BMP-2 demonstrated more cell spreading and proliferation compared to those of the Gel-Pec-BCP scaffolds.

Original languageEnglish
Article number41241
JournalJournal of Applied Polymer Science
Issue number2
Publication statusPublished - Jan 2015
Externally publishedYes


  • Biocompatibility
  • Biomaterials
  • Porous materials

Field of Science*

  • 1.4 Chemical sciences
  • 1.6 Biological sciences
  • 2.10 Nano-technology
  • 2.5 Materials engineering

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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