The effect of Ginkgo biloba and Camellia sinensis extracts on psychological state and glycemic control in patients with type 2 diabetes mellitus

Lina Lasaite, Asta Spadiene, Nijole Savickiene, Andrejs Skesters, Alise Silova

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)
2 Downloads (Pure)

Abstract

Interest in finding natural antioxidants for use in food or medical materials to prevent free radical imbalance has increased considerably over the past years. The aim of this research was to evaluate changes in glycemic control and psychological state of patients with type 2 diabetes mellitus (T2DM) after use of antioxidant plant preparations. Fifty-six patients with T2DM were randomly allocated to receive standardized Ginkgo biloba L. leaves dry extract, green tea dry extract, or placebo capsules. Diabetes glycemic control measured as glycated hemoglobin (HbA1c) level, antioxidant state and psychological data were evaluated at baseline, after 9 and 18 months of using either antioxidant preparations or placebo. The level of perceived stress lowered significantly after 9 months (p=0.038) and 18 months (p=0.030), and the psychological aspect of quality of life significantly improved after 18 months (p=0.019) of use of G. biloba extract. No significant differences were detected after using green tea extract. In patients using placebo, significant lowering of HbA1c level was observed after 18 months (p=0.017). In conclusion, antioxidant G. biloba leaf extract exhibited a mild effect on psychological state and a trend of improving glycemic control in patients with type 2 diabetes mellitus.

Original languageEnglish
Pages (from-to)1345-1350
Number of pages6
JournalNatural Product Communications
Volume9
Issue number9
DOIs
Publication statusPublished - Sep 2014

Keywords*

  • Emotional state
  • Ginkgo biloba L. extract
  • Green tea ( Camellia sinensis L.) extract
  • Perceived stress
  • Quality of life
  • Type 2 diabetes mellitus

Field of Science*

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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