The effect of intranasally administered tlr3 agonist larifan on metabolic profile of microglial cells in rat with c6 glioma

Y. Hurmach, M. Rudyk, V. Svyatetska, N. Senchylo, O. Skachkova, D. Pjanova, K. Vaivode, L. Skivka

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Abstract

Glioma-associated microglia/macrophages (Gam) represent an attractive therapeutic target for the development of the alternative methodology in the treatment of gliomas. This study was aimed to investigate the effect of intranasally administered TLR3 agonist Larifan on microglial cell metabolic profile in rats with C6 glioma. Our results demonstrate progressive generation microglial cell population with immunosuppressive and pro-inflammatory properties in C6 glioma-bearing brain. Intranasally delivered TLR3 agonist is capable to abrogate the creation of this pro-tumoral immune infiltrates, probably, through the effect on myeloid-derived suppressor cells, and can be considered as a promising agent for glioma therapy aimed the Gam re-education.

Original languageEnglish
Pages (from-to)110-119
Number of pages10
JournalUkrainian Biochemical Journal
Volume90
Issue number6
DOIs
Publication statusPublished - 2018
Externally publishedYes

Keywords*

  • Glioma
  • Immunotherapy
  • Microglia
  • Toll-like receptor agonist

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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