The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation

J. Vamze, M. Pilmane, A. Skagers

Research output: Contribution to journalConference articlepeer-review

Abstract

Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.

Original languageEnglish
Article number012025
JournalIOP Conference Series: Materials Science and Engineering
Volume38
Issue number1
DOIs
Publication statusPublished - 2012
EventInternational Conference on Functional Materials and Nanotechnologies - Riga, Latvia
Duration: 17 Apr 201220 Apr 2012

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine
  • 2.5 Materials emgineering
  • 2.6 Medical engineering

Publication Type

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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