The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation

J. Vamze; M. Pilmane; A. Skagers

doi:10.1088/1757-899X/38/1/012025

The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation

J. Vamze^*
, M. Pilmane
, A. Skagers

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

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Abstract

Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.

Original language	English
DOIs	https://doi.org/10.1088/1757-899X/38/1/012025
Publication status	Published - 2012
Event	International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012) - Institute of Solid State Physics, University of Latvia, Riga, Latvia Duration: 17 Apr 2012 → 20 Apr 2012 https://www.cfi.lu.lv/lv/notikumi/konferences/cfiorganizetasstarptautiskaskonferencesunpasakumi/gadskarteja-functional-materials-and-nanotechnologies-konference/fmnt-2012/

Conference

Conference	International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012)
Abbreviated title	FM&NT-2012
Country/Territory	Latvia
City	Riga
Period	17/04/12 → 20/04/12
Other	International Conference on Functional Materials and Nanotechnologies
Internet address	https://www.cfi.lu.lv/lv/notikumi/konferences/cfiorganizetasstarptautiskaskonferencesunpasakumi/gadskarteja-functional-materials-and-nanotechnologies-konference/fmnt-2012/

Field of Science*

2.6 Medical engineering
3.2 Clinical medicine
2.5 Materials engineering
3.1 Basic medicine

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

Access to Document

10.1088/1757-899X/38/1/012025Licence: CC BY

The expression of cytokinesFinal published version, 970 KBLicence: CC BY

Cite this

Vamze, J., Pilmane, M., & Skagers, A. (2012). The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation. Paper presented at International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012), Riga, Latvia. https://doi.org/10.1088/1757-899X/38/1/012025

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title = "The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation",

abstract = "Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.",

author = "J. Vamze and M. Pilmane and A. Skagers",

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note = "International Conference {"}Functional Materials and Nanotechnologies{"} (FM\&NT-2012), FM\&NT-2012 ; Conference date: 17-04-2012 Through 20-04-2012",

url = "https://www.cfi.lu.lv/lv/notikumi/konferences/cfiorganizetasstarptautiskaskonferencesunpasakumi/gadskarteja-functional-materials-and-nanotechnologies-konference/fmnt-2012/",

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Vamze, J , Pilmane, M & Skagers, A 2012, 'The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation', Paper presented at International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012), Riga, Latvia, 17/04/12 - 20/04/12. https://doi.org/10.1088/1757-899X/38/1/012025

The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation. / Vamze, J.; Pilmane, M.; Skagers, A.
2012. Paper presented at International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012), Riga, Latvia.

Research output: Contribution to conference › Paper › peer-review

TY - CONF

T1 - The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation

AU - Vamze, J.

AU - Pilmane, M.

AU - Skagers, A.

PY - 2012

Y1 - 2012

N2 - Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.

AB - Bone loss induced by inflammation is one of the complications after biomaterial implantation. There is no much data on expression of cytokines and defensins into the bone tissue around the implants in literature. The aim of this work was to investigate the distribution and appearance of interleukin (IL)-1, IL-6, IL-8, IL-10 and (β - defensin (BD)-2, BD-3, BD-4 after the implantation of different biomaterials. Bone developing zones, signs of bone-implant contact and low expression of pro-inflammatory cytokine IL-1, IL-6 and anti-inflammatory cytokine IL-10 in experimental tissue with pure HAp and unburned HAp implants indicate a potential advantage of this material in terms of its biocompatibility over the other materials used in our study.

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U2 - 10.1088/1757-899X/38/1/012025

DO - 10.1088/1757-899X/38/1/012025

M3 - Paper

AN - SCOPUS:84874050919

T2 - International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012)

Y2 - 17 April 2012 through 20 April 2012

ER -

Vamze J , Pilmane M, Skagers A. The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation. 2012. Paper presented at International Conference "Functional Materials and Nanotechnologies" (FM&NT-2012), Riga, Latvia. doi: 10.1088/1757-899X/38/1/012025

The expression of cytokines and β -defensin 2, - 3, -4 in rabbit bone tissue after hydroxyapatite (HAp), α- Tricalcium phosphate (α-TCP) and polymethylmethacrylate (PMMA) implantation

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