The fifth cranial nerve in headaches

J. C.A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D'Ettore, I. Frattale, M. Kurnukhina, N. MacErola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina, G. Vanderschueren, Linda Zvaune, A. P. Andreou, K. A. Haanes

Research output: Contribution to journalReview articlepeer-review

80 Citations (Scopus)


The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

Original languageEnglish
Article number65
JournalJournal of Headache and Pain
Issue number1
Publication statusPublished - 5 Jun 2020
Externally publishedYes


  • CGRP
  • Fifth cranial nerve
  • Headache
  • Migraine pathophysiology
  • Treatments
  • Trigeminal ganglion

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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