The fifth cranial nerve in headaches

J. C.A. Edvinsson; A. Viganò; A. Alekseeva; E. Alieva; R. Arruda; C. De Luca; N. D'Ettore; I. Frattale; M. Kurnukhina; N. MacErola; E. Malenkova; M. Maiorova; A. Novikova; P. Řehulka; V. Rapaccini; O. Roshchina; G. Vanderschueren; Linda Zvaune; A. P. Andreou; K. A. Haanes

doi:10.1186/s10194-020-01134-1

The fifth cranial nerve in headaches

J. C.A. Edvinsson, A. Viganò, A. Alekseeva, E. Alieva, R. Arruda, C. De Luca, N. D'Ettore, I. Frattale, M. Kurnukhina, N. MacErola, E. Malenkova, M. Maiorova, A. Novikova, P. Řehulka, V. Rapaccini, O. Roshchina, G. Vanderschueren, Linda Zvaune, A. P. Andreou, K. A. Haanes

Research output: Contribution to journal › Review article › peer-review

89 Citations (Scopus)

Abstract

The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

Original language	English
Article number	65
Journal	Journal of Headache and Pain
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s10194-020-01134-1
Publication status	Published - 5 Jun 2020
Externally published	Yes

Keywords*

CGRP
Fifth cranial nerve
Headache
Migraine pathophysiology
Treatments
Trigeminal ganglion

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1186/s10194-020-01134-1

Cite this

Edvinsson, J. C. A., Viganò, A., Alekseeva, A., Alieva, E., Arruda, R., De Luca, C., D'Ettore, N., Frattale, I., Kurnukhina, M., MacErola, N., Malenkova, E., Maiorova, M., Novikova, A., Řehulka, P., Rapaccini, V., Roshchina, O., Vanderschueren, G., Zvaune, L., Andreou, A. P., & Haanes, K. A. (2020). The fifth cranial nerve in headaches. Journal of Headache and Pain, 21(1), Article 65. https://doi.org/10.1186/s10194-020-01134-1

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title = "The fifth cranial nerve in headaches",

abstract = "The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.",

keywords = "CGRP, Fifth cranial nerve, Headache, Migraine pathophysiology, Treatments, Trigeminal ganglion",

author = "Edvinsson, {J. C.A.} and A. Vigan{\`o} and A. Alekseeva and E. Alieva and R. Arruda and {De Luca}, C. and N. D'Ettore and I. Frattale and M. Kurnukhina and N. MacErola and E. Malenkova and M. Maiorova and A. Novikova and P. {\v R}ehulka and V. Rapaccini and O. Roshchina and G. Vanderschueren and Linda Zvaune and Andreou, {A. P.} and Haanes, {K. A.}",

year = "2020",

month = jun,

day = "5",

doi = "10.1186/s10194-020-01134-1",

language = "English",

volume = "21",

journal = "Journal of Headache and Pain",

issn = "1129-2369",

publisher = "Springer-Verlag Italia",

number = "1",

}

Edvinsson, JCA, Viganò, A, Alekseeva, A, Alieva, E, Arruda, R, De Luca, C, D'Ettore, N, Frattale, I, Kurnukhina, M, MacErola, N, Malenkova, E, Maiorova, M, Novikova, A, Řehulka, P, Rapaccini, V, Roshchina, O, Vanderschueren, G, Zvaune, L, Andreou, AP & Haanes, KA 2020, 'The fifth cranial nerve in headaches', Journal of Headache and Pain, vol. 21, no. 1, 65. https://doi.org/10.1186/s10194-020-01134-1

TY - JOUR

T1 - The fifth cranial nerve in headaches

AU - Edvinsson, J. C.A.

AU - Viganò, A.

AU - Alekseeva, A.

AU - Alieva, E.

AU - Arruda, R.

AU - De Luca, C.

AU - D'Ettore, N.

AU - Frattale, I.

AU - Kurnukhina, M.

AU - MacErola, N.

AU - Malenkova, E.

AU - Maiorova, M.

AU - Novikova, A.

AU - Řehulka, P.

AU - Rapaccini, V.

AU - Roshchina, O.

AU - Vanderschueren, G.

AU - Zvaune, Linda

AU - Andreou, A. P.

AU - Haanes, K. A.

PY - 2020/6/5

Y1 - 2020/6/5

N2 - The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

AB - The fifth cranial nerve is the common denominator for many headaches and facial pain pathologies currently known. Projecting from the trigeminal ganglion, in a bipolar manner, it connects to the brainstem and supplies various parts of the head and face with sensory innervation. In this review, we describe the neuroanatomical structures and pathways implicated in the sensation of the trigeminal system. Furthermore, we present the current understanding of several primary headaches, painful neuropathies and their pharmacological treatments. We hope that this overview can elucidate the complex field of headache pathologies, and their link to the trigeminal nerve, to a broader field of young scientists.

KW - CGRP

KW - Fifth cranial nerve

KW - Headache

KW - Migraine pathophysiology

KW - Treatments

KW - Trigeminal ganglion

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U2 - 10.1186/s10194-020-01134-1

DO - 10.1186/s10194-020-01134-1

M3 - Review article

C2 - 32503421

AN - SCOPUS:85086052280

SN - 1129-2369

VL - 21

JO - Journal of Headache and Pain

JF - Journal of Headache and Pain

IS - 1

M1 - 65

ER -

The fifth cranial nerve in headaches

Abstract

Keywords*

Field of Science*

Publication Type*

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