The frequency of HLA-DR alleles in patients with tick-borne disease from Latvia

Lilija Kovalchuka, Jeļena Eglīte, Mara Zalite, Irina Lucenko, Ināra Logina, Guntis Karelis, Ludmila Vīksna, Angelika Krūmiņa

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Background: The level of incidence of Tick-borne disease in Latvia still is one of the highest in Europe.
There are some similarities between the viral agents, and HLA molecules, because in organism develops
one way or another immune response to infection. Clarifying the polymorphisms of HLA molecules will
allow to identify regularities of pathological process and to develop a new approach to treating these
The purpose: Of this study was to determine HLA-DR alleles in two groups Latvian patients: in patients
with Lyme borreliosis (LB) and patients with Tick-borne encephalitis (TBE). The study included 38 patients
with clinical stage –erythema migrans, 60 patients with TBE and 100 control (healthy) persons.All patients
and healthy persons are residents of Latvia. HLA genotyping was performed by PCR with sequence-specific
Results: The frequency of HLA-DRB1*17(03) (odds ratio, 4.06; pc=0.003), HLA-DRB1*04 (odds ratio,
3.22; pc=0.162), and HLA-DRB1*13 (odds ratio, 2.37; pc=0.055), were higher in patients with LB. And
the HLA-DRB1*10 (odds ratio, 0.16; pc=0.044) was smaller in LB patients and significantly higher in
controls. Among TBE patients the HLA-DRB1*04 (11 percent vs. 5 percent; odds ratio, 2.58; pc=0.386) and
DRB1*17(03) (10 percent vs. 4 percent; odds ratio, 2.67; pc=0.396) alleles were increased, but the HLADRB1*01 (2 percent vs. 6 percent; odds ratio, 0.13; pc=0.240) was lower in patients, these differences were not significant after Bonferroni correction.
Conclusions: These data suggest the positive association of HLA-DRB1*17(03) allele with Lyme borreliosis
in Latvian patients, and HLA-DRB1*10 allele could be associated with a potential protective effect. Among
TBE patients statistically significant associations of HLA-DRB1 not detected.
Original languageEnglish
Article number4
Number of pages6
JournalResearch Journal of Infectious Diseases
Publication statusPublished - 2014


  • Tick-borne diseases
  • HLA alleles
  • marker
  • PCR

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)


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