The function of the isolated heterologous liver perfused with the human blood

M. S. Margulis, D. B. Krivulis, R. L. Rosental, G. I. Cimmerman, E. A. Kvizinskaja, A. A. Brence

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

The metabolic changes and their influence on the isolated liver were studied in 21 experiments on pig liver, perfused with human blood during the period of 3 hrs. It was detected, that rather active carbohydrate and nitrogenic metabolism has been maintained in the liver during 1.5-2 hrs. But after the 2nd hr of perfusion the phenomens of perfusion the phenomens of hypoxia increased, that caused the inhibition of metabolic processes and leaded to deterioration of liver function. The experience of clinical perfusions showed, that the functional activity of assisted liver over the period of 90 min was so depressed, that the organ couldn't provide positive clinical effect.

Translated title of the contributionThe function of the isolated heterologous liver perfused with the human blood
Original languageGerman
Pages (from-to)75-78
Number of pages4
JournalResearch in Experimental Medicine
Volume165
Issue number1
DOIs
Publication statusPublished - Feb 1975
Externally publishedYes

Keywords

  • Heterologous liver perfusion
  • Liver conservation
  • Liver metabolism
  • Pig liver
  • Temporary liver substitution

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'The function of the isolated heterologous liver perfused with the human blood'. Together they form a unique fingerprint.

Cite this