The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

Thorsten Kessler; Baiba Vilne; Heribert Schunkert

doi:10.15252/emmm.201506174

The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease

Thorsten Kessler
, Baiba Vilne
, Heribert Schunkert

Research output: Contribution to journal › Review article › peer-review

149 Citations (Scopus)

16 Downloads (Pure)

Abstract

Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome-wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk-related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.

Original language	English
Pages (from-to)	688-701
Number of pages	14
Journal	EMBO Molecular Medicine
Volume	8
Issue number	7
DOIs	https://doi.org/10.15252/emmm.201506174
Publication status	Published - 1 Jul 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

atherosclerosis
coronary artery disease
genome-wide association studies
myocardial infarction

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.15252/emmm.201506174

The impact of genome‐wide association studiesFinal published version, 1.15 MBLicence: CC BY

Cite this

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title = "The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease",

abstract = "Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly with traditional risk factors precipitates their manifestation. Whereas the implications of a positive family history for individual risk have been known for a long time, only in the past few years have genome-wide association studies (GWAS) shed light on the underlying genetic variations. Here, we review these studies designed to increase our understanding of the pathophysiology of cardiovascular diseases, particularly coronary artery disease and myocardial infarction. We focus on the newly established pathways to exemplify the translation from the identification of risk-related genetic variants to new preventive and therapeutic strategies for cardiovascular disease.",

keywords = "atherosclerosis, coronary artery disease, genome-wide association studies, myocardial infarction",

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note = "Funding Information: This work was supported by grants from the Fondation Leducq (CADgenomics: Understanding CAD Genes, 12CVD02), the German Federal Ministry of Education and Research (BMBF) within the framework of the e: Med research and funding concept (e:AtheroSysMed, grant 01ZX1313A-2014) and the European Union Seventh Framework Programme FP7/2007-2013 under grant agreement no. HEALTH-F2-2013-601456 (CVgenes-at-target). Further grants were received from the DFG as part of the Sonderforschungsbereich CRC 1123 (B2). T.K. was supported by a DZHK Rotation Grant. Figures and contain modified image material available at Servier Medical Art under a Creative Commons Attribution 3.0 Unported License. Publisher Copyright: {\textcopyright} 2016 The Authors. Published under the terms of the CC BY 4.0 license Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",

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doi = "10.15252/emmm.201506174",

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AU - Vilne, Baiba

AU - Schunkert, Heribert

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