Abstract
We have examined the effect of kynurenine, neopterin and norepinephrine on epithelial cells and fibroblasts: the total DNA synthesis (by adding 3H-thymidine), the mitotic index, the amount of pathological mitosis and apoptosis. We have observed that kynurenine, neopterin and norepinephrine induce pathological mitosis and apoptosis of epithelial cells of kidney. The total DNA synthesis increases by the incubation of the epithelial cells with neopterin and norepinephrine. We have found an increase of pathological mitosis after addition of kynurenine, neopterin and norepinephrine to fibroblast cell culture. The total DNA synthesis is promoted by neopterin and norepinephrine, while kynurenine does not alter it. These data allow us to suggest that kynurenine, neopterin and norepinephrine promote epithelial cell damage leading to cell death through apoptosis, and can therefore be added to the factors, which promote the pathological mitosis of fibroblasts.
| Original language | English |
|---|---|
| Pages (from-to) | 347-352 |
| Number of pages | 6 |
| Journal | Advances in Experimental Medicine and Biology |
| Volume | 467 |
| Publication status | Published - 2000 |
| Event | 9th Meeting of the International Study Group for Tryptophan Research (ISTRY): Tryptophan-Basic Aspects and Practical Applications - Hamburg, Germany Duration: 10 Oct 1998 → 14 Oct 1998 Conference number: 9 https://www.istry.org/about/history/ |
Field of Science*
- 1.6 Biological sciences
- 1.4 Chemical sciences
Publication Type*
- 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database