The influence of kynurenine, neopterin, and norepinephrine on tubular epithelial cells and alveolar fibroblasts

A. Martinsons, V. Rudzite, O. Bratslavska, V. Saulite

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We have examined the effect of kynurenine, neopterin and norepinephrine on epithelial cells and fibroblasts: the total DNA synthesis (by adding 3H-thymidine), the mitotic index, the amount of pathological mitosis and apoptosis. We have observed that kynurenine, neopterin and norepinephrine induce pathological mitosis and apoptosis of epithelial cells of kidney. The total DNA synthesis increases by the incubation of the epithelial cells with neopterin and norepinephrine. We have found an increase of pathological mitosis after addition of kynurenine, neopterin and norepinephrine to fibroblast cell culture. The total DNA synthesis is promoted by neopterin and norepinephrine, while kynurenine does not alter it. These data allow us to suggest that kynurenine, neopterin and norepinephrine promote epithelial cell damage leading to cell death through apoptosis, and can therefore be added to the factors, which promote the pathological mitosis of fibroblasts.

Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalAdvances in Experimental Medicine and Biology
Volume467
Publication statusPublished - 2000
Event9th Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY 98) - HAMBURG, GERMANY, HAMBURG, Germany
Duration: 10 Oct 199814 Oct 1998

Field of Science

  • 1.6 Biological sciences
  • 1.4 Chemical sciences

Publication Type

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database

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