Abstract
The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.
| Original language | English |
|---|---|
| Title of host publication | DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM |
| Publisher | Springer US |
| Pages | 337-345 |
| Number of pages | 9 |
| ISBN (Electronic) | 978-1-4615-0135-0 |
| ISBN (Print) | 978-0-306-47755-3 |
| Publication status | Published - 2003 |
| Event | 10th International Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY) - Padova, Italy Duration: 25 Jun 2002 → 29 Jun 2002 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Publisher | Springer US |
| Volume | 527 |
| ISSN (Print) | 0065-2598 |
Meeting
| Meeting | 10th International Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY) |
|---|---|
| Country/Territory | Italy |
| City | Padova |
| Period | 25/06/02 → 29/06/02 |
Field of Science*
- 3.1 Basic medicine
- 3.2 Clinical medicine
Publication Type*
- 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database