The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure

Agris Martinsons; Vera Rudzite; Harijis Cernevskis; Inese Mihailova; Zane Smeltere

The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure

Agris Martinsons, Vera Rudzite, Harijis Cernevskis, Inese Mihailova, Zane Smeltere

Department of Internal Diseases

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Citations (Scopus)

Abstract

The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.

Original language	English
Title of host publication	DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM
Publisher	Springer US
Pages	337-345
Number of pages	9
ISBN (Electronic)	978-1-4615-0135-0
ISBN (Print)	978-0-306-47755-3
Publication status	Published - 2003
Event	10th Meeting of the International Study Group for Tryptophan Research (ISTRY) - Padova, Italy Duration: 25 Jun 2002 → 29 Jun 2002 Conference number: 10 https://www.istry.org/about/history/

Publication series

Name	Advances in Experimental Medicine and Biology
Publisher	Springer US
Volume	527
ISSN (Print)	0065-2598

Meeting

Meeting	10th Meeting of the International Study Group for Tryptophan Research (ISTRY)
Abbreviated title	ISTRY 2002
Country/Territory	Italy
City	Padova
Period	25/06/02 → 29/06/02
Internet address	https://www.istry.org/about/history/

Field of Science*

3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

Access to Document

https://link.springer.com/chapter/10.1007%2F978-1-4615-0135-0_37

Cite this

Martinsons, A., Rudzite, V., Cernevskis, H., Mihailova, I., & Smeltere, Z. (2003). The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure. In DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM (pp. 337-345). (Advances in Experimental Medicine and Biology; Vol. 527). Springer US. https://link.springer.com/chapter/10.1007%2F978-1-4615-0135-0_37

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title = "The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure",

abstract = "The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.",

author = "Agris Martinsons and Vera Rudzite and Harijis Cernevskis and Inese Mihailova and Zane Smeltere",

note = "Edited by: Allegri, G. Costa, CVL, Ragazzi, E.,Steinhart, H., Varesio, L ; 10th Meeting of the International Study Group for Tryptophan Research (ISTRY), ISTRY 2002 ; Conference date: 25-06-2002 Through 29-06-2002",

year = "2003",

language = "English",

isbn = "978-0-306-47755-3",

series = "Advances in Experimental Medicine and Biology",

publisher = "Springer US",

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Martinsons, A, Rudzite, V, Cernevskis, H, Mihailova, I & Smeltere, Z 2003, The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure. in DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM. Advances in Experimental Medicine and Biology, vol. 527, Springer US, pp. 337-345, 10th Meeting of the International Study Group for Tryptophan Research (ISTRY), Padova, Italy, 25/06/02. <https://link.springer.com/chapter/10.1007%2F978-1-4615-0135-0_37>

The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure. / Martinsons, Agris; Rudzite, Vera; Cernevskis, Harijis et al.
DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM. Springer US, 2003. p. 337-345 (Advances in Experimental Medicine and Biology; Vol. 527).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

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T1 - The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure

AU - Martinsons, Agris

AU - Rudzite, Vera

AU - Cernevskis, Harijis

AU - Mihailova, Inese

AU - Smeltere, Zane

N1 - Conference code: 10

PY - 2003

Y1 - 2003

N2 - The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.

AB - The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.

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M3 - Chapter

C2 - 15206747

AN - SCOPUS:1042268001

SN - 978-0-306-47755-3

T3 - Advances in Experimental Medicine and Biology

SP - 337

EP - 345

BT - DEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM

PB - Springer US

T2 - 10th Meeting of the International Study Group for Tryptophan Research (ISTRY)

Y2 - 25 June 2002 through 29 June 2002

ER -

The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure

Abstract

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