The influence of L-tryptophan peroral load on glomerular filtration rate in chronic glomerulonephritis and chronic renal failure

Agris Martinsons, Vera Rudzite, Harijis Cernevskis, Inese Mihailova, Zane Smeltere

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Citations (Scopus)

Abstract

The results of our clinical observations of 102 patients with chronic glomerulonephritis with normal renal function and 10 patients with chronic renal failure, as well as 10 healthy individuals allow us to conclude that in patients with high proteinuria and impaired renal function the serum concentration of tryptophan is decreased, both before and after peroral L - tryptophan load. We have found a positive correlation between serum concentration of albumin and tryptophan in patients with normal kidney function, and negative correlations between serum concentration of albumin and intensity of proteinuria, as well as between serum concentration of tryptophan and proteinuria. Our studies have shown that L - tryptophan peroral load increases the glomerular filtration rate in healthy individuals, in patients with membronous proliferative glomerulonephritis with proteinuria < 2 g/24 h and mesangioproliferative glomerulonephritis with proteinuria < 2 g/24 h. In patients with high proteinuria (> 2 g/ 24h) and decreased renal function L - tryptophan load does not influence the glomerular filtration rate.

Original languageEnglish
Title of host publicationDEVELOPMENTS IN TRYPTOPHAN AND SEROTONIN METABOLISM
PublisherSpringer US
Pages337-345
Number of pages9
ISBN (Electronic) 978-1-4615-0135-0
ISBN (Print)978-0-306-47755-3
Publication statusPublished - 2003
Event
10th International Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY)
- Padova, Italy
Duration: 25 Jun 200229 Jun 2002

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer US
Volume527
ISSN (Print)0065-2598

Meeting

Meeting
10th International Meeting of the International-Study-Group-for-Tryptophan-Research (ISTRY)
Country/TerritoryItaly
CityPadova
Period25/06/0229/06/02

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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