The Influence Of The Oral Microbiome On General Health

Johannes Friedrich Carl Rohr (Coresponding Author), Aldis Rozenblats, Guntars Selga, Ingrīda Čēma

    Research output: Contribution to journalReview articlepeer-review

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    Background The oral microbiome hosts a large number of microorganisms that play a critical role in oral and
    general health. Many factors can cause dysbiosis of the otherwise beneficial interrelationship between host
    and microbiome. Understanding and identifying microbial shifts and keystone pathogens that correlate
    with general diseases of the body holds many opportunities.
    Objective The aim of this literature review is to present scientific evidence about disease-associated
    microbial shifts in the oral cavity, the effect on oral and general health and give the reader insights into
    alternative, new treatment approaches. This review is also intended to inspire practitioners to consider a
    more holistic care approach.
    Data sources A search was performed using PubMed, Google Scholar and ScienceDirect. The general key
    terms used were: “Oral microbiome AND health”, “Oral microbiome AND general disease”. Disease-specific
    searches were performed. Articles found by cross-referencing were included.
    Study selection Original studies and meta-analyses were included. Articles published in 2012 or later were
    preferentially considered. Reviews were included if deemed valuable and labelled in the text. Articles not
    written in English were excluded.
    Data extraction The reviewer assessed each article for their relevance and methodology. Results were
    evaluated according to their sample size and whether or not the same result was replicated in different
    Data synthesis Individual etiological factors correlate with several, seemingly unrelated diseases. This article
    directs the reader towards understanding the more unusual interconnections and utilizing multidisciplinary
    treatment approaches, that are aimed at reestablishing an overall balance within the oral microbiome.
    Original languageEnglish
    Pages (from-to)66-76
    JournalStomatology Edu Journal
    Issue number1
    Publication statusPublished - 11 Mar 2021


    • Oral Microbiome
    • Systemic Diseases
    • Oral Health
    • Probiotics
    • Dysbiosis

    Field of Science*

    • 3.2 Clinical medicine

    Publication Type*

    • 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)


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