The Influence Of The Oral Microbiome On General Health

Johannes Friedrich Carl Rohr (Coresponding Author), Aldis Rozenblats, Guntars Selga, Ingrīda Čēma

Research output: Contribution to journalReview articlepeer-review


Background The oral microbiome hosts a large number of microorganisms that play a critical role in oral and
general health. Many factors can cause dysbiosis of the otherwise beneficial interrelationship between host
and microbiome. Understanding and identifying microbial shifts and keystone pathogens that correlate
with general diseases of the body holds many opportunities.
Objective The aim of this literature review is to present scientific evidence about disease-associated
microbial shifts in the oral cavity, the effect on oral and general health and give the reader insights into
alternative, new treatment approaches. This review is also intended to inspire practitioners to consider a
more holistic care approach.
Data sources A search was performed using PubMed, Google Scholar and ScienceDirect. The general key
terms used were: “Oral microbiome AND health”, “Oral microbiome AND general disease”. Disease-specific
searches were performed. Articles found by cross-referencing were included.
Study selection Original studies and meta-analyses were included. Articles published in 2012 or later were
preferentially considered. Reviews were included if deemed valuable and labelled in the text. Articles not
written in English were excluded.
Data extraction The reviewer assessed each article for their relevance and methodology. Results were
evaluated according to their sample size and whether or not the same result was replicated in different
Data synthesis Individual etiological factors correlate with several, seemingly unrelated diseases. This article
directs the reader towards understanding the more unusual interconnections and utilizing multidisciplinary
treatment approaches, that are aimed at reestablishing an overall balance within the oral microbiome.
Original languageEnglish
Pages (from-to)66-76
JournalStomatology Edu Journal
Issue number1
Publication statusPublished - 11 Mar 2021


  • Oral Microbiome
  • Systemic Diseases
  • Oral Health
  • Probiotics
  • Dysbiosis

Field of Science

  • 3.2 Clinical medicine

Publication Type

  • 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)


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