The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia

Oksana Kolesova; Monta Madelane; Ilze Ekšteina; Aleksandrs Kolesovs; Angelika Krumina; Ludmila Viksna

doi:10.2478/prolas-2020-0015

The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia

Oksana Kolesova (Corresponding Author), Monta Madelane, Ilze Ekšteina, Aleksandrs Kolesovs, Angelika Krumina, Ludmila Viksna

Research output: Contribution to journal › Article › peer-review

55 Downloads (Pure)

Abstract

Cytokeratin 18 (CK18) is a specific marker of hepatocellular apoptosis, which is a useful noninvasive indicator of liver fibrosis in the HIV/HCV group. However, data on the CK18 level in serum are limited for this group. This study demonstrated CK18 levels in serum in HIV/HCV coinfected and HIV mono-infected patients; investigated the association of CK18 levels with other non-invasive markers of liver fibrosis; and presents CK18 dynamics in a four-month-long period. The sample included 273 patients with HIV infection (128 of them were with HIV/HCV coinfection) aged from 23 to 65 (35% females). Levels of hyaluronic acid, CK18, ALT, and AST were determined in serum, and the FIB4 index was calculated. All markers had higher levels in the HIV/HCV group than in the HIV mono-infection group. The HIV/HCV group demonstrated coherent correlations among the markers and their associations with the level of CK18 than the HIV mono-infection group. During the four-month-long period, the CK18 level in serum showed no significant changes.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume	74
Issue number	2
DOIs	https://doi.org/10.2478/prolas-2020-0015
Publication status	Published - 2020

Keywords*

CK18
Hepatocyte apoptosis
HIV/HCV
Liver fibrosis
Non-invasive test

Field of Science*

3.2 Clinical medicine
3.3 Health sciences

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2478/prolas-2020-0015

Level of Cytokeratin 18 in Patients with HIVLicence: CC BY-NC-ND

Cite this

@article{46ff6153feb74cbfa636cccb7acb6bcc,

title = "The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia",

abstract = "Cytokeratin 18 (CK18) is a specific marker of hepatocellular apoptosis, which is a useful noninvasive indicator of liver fibrosis in the HIV/HCV group. However, data on the CK18 level in serum are limited for this group. This study demonstrated CK18 levels in serum in HIV/HCV coinfected and HIV mono-infected patients; investigated the association of CK18 levels with other non-invasive markers of liver fibrosis; and presents CK18 dynamics in a four-month-long period. The sample included 273 patients with HIV infection (128 of them were with HIV/HCV coinfection) aged from 23 to 65 (35% females). Levels of hyaluronic acid, CK18, ALT, and AST were determined in serum, and the FIB4 index was calculated. All markers had higher levels in the HIV/HCV group than in the HIV mono-infection group. The HIV/HCV group demonstrated coherent correlations among the markers and their associations with the level of CK18 than the HIV mono-infection group. During the four-month-long period, the CK18 level in serum showed no significant changes.",

keywords = "CK18, Hepatocyte apoptosis, HIV/HCV, Liver fibrosis, Non-invasive test",

author = "Oksana Kolesova and Monta Madelane and Ilze Ek{\v s}teina and Aleksandrs Kolesovs and Angelika Krumina and Ludmila Viksna",

year = "2020",

doi = "10.2478/prolas-2020-0015",

language = "English",

volume = "74",

pages = "94--99",

journal = "Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences",

issn = "1407-009X",

publisher = "de Gruyter",

number = "2",

}

The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia. / Kolesova, Oksana (Corresponding Author); Madelane, Monta; Ekšteina, Ilze et al.
In: Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences, Vol. 74, No. 2, 2020, p. 94-99.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia

AU - Kolesova, Oksana

AU - Madelane, Monta

AU - Ekšteina, Ilze

AU - Kolesovs, Aleksandrs

AU - Krumina, Angelika

AU - Viksna, Ludmila

PY - 2020

Y1 - 2020

N2 - Cytokeratin 18 (CK18) is a specific marker of hepatocellular apoptosis, which is a useful noninvasive indicator of liver fibrosis in the HIV/HCV group. However, data on the CK18 level in serum are limited for this group. This study demonstrated CK18 levels in serum in HIV/HCV coinfected and HIV mono-infected patients; investigated the association of CK18 levels with other non-invasive markers of liver fibrosis; and presents CK18 dynamics in a four-month-long period. The sample included 273 patients with HIV infection (128 of them were with HIV/HCV coinfection) aged from 23 to 65 (35% females). Levels of hyaluronic acid, CK18, ALT, and AST were determined in serum, and the FIB4 index was calculated. All markers had higher levels in the HIV/HCV group than in the HIV mono-infection group. The HIV/HCV group demonstrated coherent correlations among the markers and their associations with the level of CK18 than the HIV mono-infection group. During the four-month-long period, the CK18 level in serum showed no significant changes.

AB - Cytokeratin 18 (CK18) is a specific marker of hepatocellular apoptosis, which is a useful noninvasive indicator of liver fibrosis in the HIV/HCV group. However, data on the CK18 level in serum are limited for this group. This study demonstrated CK18 levels in serum in HIV/HCV coinfected and HIV mono-infected patients; investigated the association of CK18 levels with other non-invasive markers of liver fibrosis; and presents CK18 dynamics in a four-month-long period. The sample included 273 patients with HIV infection (128 of them were with HIV/HCV coinfection) aged from 23 to 65 (35% females). Levels of hyaluronic acid, CK18, ALT, and AST were determined in serum, and the FIB4 index was calculated. All markers had higher levels in the HIV/HCV group than in the HIV mono-infection group. The HIV/HCV group demonstrated coherent correlations among the markers and their associations with the level of CK18 than the HIV mono-infection group. During the four-month-long period, the CK18 level in serum showed no significant changes.

KW - CK18

KW - Hepatocyte apoptosis

KW - HIV/HCV

KW - Liver fibrosis

KW - Non-invasive test

UR - http://www.scopus.com/inward/record.url?scp=85092926408&partnerID=8YFLogxK

U2 - 10.2478/prolas-2020-0015

DO - 10.2478/prolas-2020-0015

M3 - Article

AN - SCOPUS:85092926408

SN - 1407-009X

VL - 74

SP - 94

EP - 99

JO - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

JF - Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences

IS - 2

ER -

The level of cytokeratin 18 in patients with HIV and viral hepatitis C co-infection in Latvia

Abstract

Keywords*

Field of Science*

Publication Type*

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this