The level of inflammatory cytokines and antimicrobial peptides after composite material implantation and contamination with bacterial culture

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Citations (Scopus)

Abstract

As biomaterial implantation is a traumatic process, especially if the implanted object becomes contaminated by bacteria, it can cause a significant increase in the production of inflammatory cytokines. An increase in the level of inflammatory cytokines can be used as a marker of biomaterial associated infection (BAI) in surrounding tissues. To prevent BAI and production of inflammatory cytokines, biomaterials with antibiotics should be used, in particular biomaterials with prolonged release of antibiotics. In this in vivo study, the level of inflammatory cytokines (interleukine - 10 (IL-10), beta-defensin-2 and tumor necrosis factors (TNF-alpha)) was determined in surrounding tissues after composite material implantation in vivo and wound contamination with Staphylococcus epidermidis (S. epidermidis) or Pseudomonas aeruginosa (P. aeruginosa). The results show that the level of inflammatory cytokines is normal in surrounding tissues after implantation of biomaterials with prolonged release of antibiotics. Biomaterials with rapid release of antibiotics also show normal levels of inflammatory cytokines. The level of inflammatory cytokines increases in cases if biomaterials without antibiotics are implanted in vivo, thus being an indication of inflammation process and BAI.

Original languageEnglish
Title of host publicationEngineering Materials and Tribology XXV
EditorsDagnija Loca
PublisherTrans Tech Publications Ltd
Pages245-250
Number of pages6
ISBN (Print)9783035710724
DOIs
Publication statusPublished - 2017
Event25th International Baltic Conference of Engineering Materials and Tribology – BALTMATTRIB - Riga, Latvia
Duration: 3 Nov 20164 Nov 2016
Conference number: 25

Publication series

NameKey Engineering Materials
Volume721 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Conference

Conference25th International Baltic Conference of Engineering Materials and Tribology – BALTMATTRIB
Country/TerritoryLatvia
CityRiga
Period3/11/164/11/16

Keywords*

  • Beta-defensin-2
  • IL-10
  • P. aeruginosa
  • S. epidermidis
  • TNF-alpha

Field of Science*

  • 2.5 Materials engineering
  • 1.6 Biological sciences

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'The level of inflammatory cytokines and antimicrobial peptides after composite material implantation and contamination with bacterial culture'. Together they form a unique fingerprint.

Cite this