The Profile of Axial Spondyloarthritis Patients According to Fatigue Level

J Zepa, I Bulina, V Lavrentjevs, J Arajs, E Sikora, L Nikitina-Zake, A Lejnieks, D Andersone

Research output: Contribution to journalMeeting Abstractpeer-review


Background and objectives. One of the most frequently reported symptoms by patients with axial spondyloarthritis (AxSpA) is disease-related fatigue. The role of fatigue and its degree during the course of AxSpA still remains a challenge. The objective of this study was to characterise the patients with AxSpA accordingly to the evaluation of disease-related fatigue.

Materials and methods. 120 patients were included in the cross-sectional study fulfilling the Assessment of Spondyloarthritis international Society (ASAS) classification criteria for AxSpA. Fatigue was evaluated using the first item of the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) questionnaire. Patients were divided into two groups: with the evaluation of fatigue ≤5 and >5. The following variables were chosen for characteristics of the groups: age, duration of the disease, the age of AxSpA onset, duration of morning stiffness, Ankylosing Spondylitis Disease Activity Score (ASDAS) (using c-reactive protein (CRP)), functional (BASFI) and metrological (BASMI) indices, the evaluation of enthesitis using the fourth item of the BASDAI questionnaire.

Results. The mean BASDAI fatigue score was 5.0 (SD 2.59). In our data, 44.2% of patients experienced severe fatigue (score >5). The mean value of age, duration of morning stiffness, ASDAS, BASFI, BASMI and evaluation of enthesitis in the group with lower fatigue level was respectively 37.4 years (SD 9.63), 41 min (SD 37.97), 2.3 (SD 1.32), 2.2 (SD 2.09), 2.8 (SD 2.39) and 2.7 (SD 2.89). In the group with severe fatigue expression the mean age was 41.5 years (SD 10.09), duration of morning stiffness – 66.2 min (SD 43.06), ASDAS – 3.7 (SD 0.94), BASFI – 5.0 (SD 2.34), BASMI - 4.4 (SD 2.54), evaluation of enthesitis – 5.2 (SD 2.99). These variables were statistically different between groups. There was no difference between groups on duration of the disease and age of AxSpA onset.

Conclusions. Patients with severe fatigue had a higher level of the disease activity, functional disability and spinal mobility impairment. These results suggest that the level of fatigue can be used as one of the clinical signs which show the expression of systemic inflammation and induced impairment of mobility in the course of the disease independent of the disease duration.
Original languageEnglish
Pages (from-to)A52-A53
JournalAnnals of the Rheumatic Diseases
Issue numberSuppl.1
Publication statusPublished - Mar 2015
Externally publishedYes
Event35th European Workshop for Rheumatology Research - Budapest, Hungary
Duration: 5 Mar 20157 Mar 2015

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database


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