The proper delivery pressure for cardioplegic solution in neonatal cardiac surgery - An investigation of biomechanical and structural properties of neonatal and adult coronary arteries

N. Sikora, A. Lacis, V. Kasyanov, V. Groma, E. Ligere, V. Ozolins, L. Smits

Research output: Contribution to journalArticlepeer-review

Abstract

When cardioplegic solution is injected into coronary arteries with a pump in order to ensure myocardial protection, it is necessary to determine the correct delivery pressure to avoid damage of the heart. Biomechanical and structural properties of the neonatal coronary artery wall should be taken into account when determining the delivery pressure.We investigated twelve coronary artery specimens without cardiac pathology retrieved from autopsies of neonates 9.3 ± 9.7 days old and compared them to adult specimens with no detected atherosclerosis.There was a rapid increase in the strain until the inner pressure reached 80-100 mmHg, whilst the increase of stress in the wall of the neonatal coronary arteries was less rapid. When the pressure exceeded 100 mmHg, the increase in the strain slowed down, whilst the wall stress and modulus of elasticity began to increase rapidly. Morphologic examination of tensile properties revealed prominent affection of the vascular wall of the neonates, with accentuated redistribution (loosening) of medial myocytes and the adventitial vasa vasorum.Collectively, a raised inner pressure applied to cardioplegic solution injected into the coronary artery of a neonate may increase the risk of structural damage to the vascular wall.

Original languageEnglish
Pages (from-to)357-363
Number of pages7
JournalPerfusion (United Kingdom)
Volume28
Issue number4
DOIs
Publication statusPublished - Jul 2013

Keywords

  • biomechanical and structural properties of the vascular wall
  • cardiopulmonary bypass
  • delivery pressure for cardioplegic solution
  • neonatal coronary artery

Field of Science

  • 3.2 Clinical medicine
  • 2.6 Medical engineering

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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