The role of ceus in the evaluation of thyroid cancer: From diagnosis to local staging

Salvatore Sorrenti, Vincenzo Dolcetti, Daniele Fresilli, Giovanni Del Gaudio, Patrizia Pacini, Pintong Huang, Chiara Camponovo, Andrea Leoncini, Vito D’andrea, Daniele Pironi, Fabrizio Frattaroli, Pierpaolo Trimboli, Maija Radzina, Vito Cantisani (Coresponding Author)

Research output: Contribution to journalReview articlepeer-review

40 Citations (Scopus)
5 Downloads (Pure)


Ultrasound often represents the first diagnostic step for thyroid nodule evaluation in clinical practice, but baseline US alone is not always effective enough to achieve thyroid nodule characterization. In the last decades new ultrasound techniques, such as CEUS, have been introduced to evaluate thyroid parenchyma as recommended by EFSUMB guidelines, for use in clinical research field, although its role is not yet clear. Several papers show the potential utility of CEUS in the differential diagnosis of benign and malignant thyroid nodules and in the analysis of lymph node involvement in neoplastic pathology. Therefore, we carried out an evaluation of the literature concerning the role of CEUS in three specific areas: the characterization of the thyroid nodule, the evaluation of minimally invasive treatment and loco‐regional staging of the lymph node in proven thyroid cancer. According to evidence reported, CEUS can also play an operative role in nodular thyroid pathology as it is able to guide ablation procedures on thyroid nodule and metastatic lymph nodes, to assess the radicality of surgery, to evaluate disease relapse at the level of the margins of ablated regions and to monitor the clinical evolution of necrotic areas in immediate post‐treatment setting.

Original languageEnglish
Article number4559
Number of pages13
JournalJournal of clinical medicine
Issue number19
Publication statusPublished - 30 Sept 2021


  • CEUS
  • Lymph node
  • RF Ablation
  • Thyroid nodule
  • Thyroid nodule diagnosis

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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