The virology of human monkeypox virus (hMPXV): A brief overview

Edouard Lansiaux (Coresponding Author), Nityanand Jain (Coresponding Author), Sniedze Laivacuma, Aigars Reinis

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)
1 Downloads (Pure)


First described in 1958, the human monkeypox virus (hMPXV) is a neglected zoonotic pathogen closely associated with the smallpox virus. The virus usually spreads via close contact with the infected animal or human and has been endemic mostly in parts of the African continent. However, with the recent increase in trade, tourism, and travel, the virus has caused outbreaks in countries outside Africa. The recent outbreak in 2022 has been puzzling given the lack of epidemiological connection and the possible sexual transmission of the virus. Furthermore, there is limited understanding of the structural and pathogenetic mechanisms that are employed by the virus to invade the host cells. Henceforth, it is critical to understand the working apparatus governing the viral-immune interactions to develop effective therapeutical and prophylactic modalities. Hence, in the present short communication, we summarize the previously reported research findings regarding the virology of the human monkeypox virus.

Original languageEnglish
Article number198932
Pages (from-to)1-8
Number of pages8
JournalVirus Research
Publication statusPublished - Dec 2022


  • Global
  • hMPXV
  • Infections
  • Monkeypox virus
  • Pandemic
  • Sexual transmission
  • Virology

Field of Science*

  • 1.6 Biological sciences
  • 3.3 Health sciences

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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