Third strategy in tissue engineering: Tissue spheroids encaged into microscaffolds

Rodrigo A. Rezende, Frederico D.A.S. Pereira, Pedro Y. Noritomi, Jorge V.L. Da Silva, Vladimir Mironov, Leandra S. Baptista, Karina R. Da Silva, Radovan Borojevic, Vladimir Kasyanov, Aleksandr Ovsianikov, Jurgen Stampfl, Maria Farsari

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Tissue engineering is a biomedical technology of artificial development of living three-dimensional human tissues and organs. Tissue engineering is based on two distinct premises. First more conventional approach uses solid biodegradable porous scaffolds as a temporal supporting framework for living cells attachment and sequential formation of three-dimensional tissue whereas second emerging approach is a solid scaffold-free directed tissue self-assembly with using tissue spheroids or microtissues as building blocks. In this paper novel hybrid approach or so-called third strategy in tissue engineering which combines advantages of first and second approaches is presented. The novel concept of lockyballs or tissue spheroids encaged into interlockable synthetic microscaffolds is described.

Original languageEnglish
Title of host publicationProceedings of the 1st International Conference on Progress in Additive Manufacturing, Pro-AM 2014
EditorsChee Kai Chua, Wai Yee Yeong, Ming Jen Tan, Erjia Liu
Number of pages6
ISBN (Electronic)9789810904463
Publication statusPublished - 2014
EventProgress in Additive Manufacturing: 1st International Confrence - Singapore
Duration: 26 May 201428 May 2014
Conference number: 1

Publication series

NameProceedings of the International Conference on Progress in Additive Manufacturing
ISSN (Print)2424-8967


ConferenceProgress in Additive Manufacturing


  • Interlockable lockyballs
  • Microscaffolds
  • Photo-sensitive biomaterials
  • Tissue engineering
  • Tissue spheroids
  • Two photon polymerization

Field of Science*

  • 2.6 Medical engineering
  • 2.5 Materials engineering

Publication Type*

  • 3.3. Publications in conference proceedings indexed in Web of Science and/or Scopus database


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