Time-dependent cytokine expression in bone of experimental animals after hydroxyapatite (Hap) implantation

M. Pilmane, G. Salms, I. Salma, A. Skagers, J. Locs, D. Loca, L. Berzina-Cimdina

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Citation (Scopus)
1 Downloads (Pure)


Proinflammatory cytokines mediate bone loss around the implants in patients with peri-implant disease. However, there is no complete data about the expression of cytokines into the bone around the implants. The aim of this work was to investigate the distribution and appearance of inflammatory cytokines and anti-inflammatory proteins in the bone of jaw of experimental rabbits in different time periods after HAp implantation. Material was obtained from 8 rabbits in lower jaw 6 and 8 months after HAp implants were placed. Tissues were processed for immunohistochemical detection of tumor necrosis factor alfa (TNFα), Interleukin 1, 6, 8, 10 (IL-1, IL-6, IL-8, IL-10) and defensin 2. Results demonstrated practically unchanged expression of IL-6 and IL-10 between both - experimental and control side 6 months after implantation, while IL-1 and IL-8 notably increased in control side. IL-1 and IL-10 expression did not change in either the experimental side nor the controle side after 8 months HAP implantation, but IL-6 and IL-8 demonstrated a decrease in the control sites. Only IL-8 was elevated with time in experimental sites, while IL-10 showed individual variations in 2 cases.

Original languageEnglish
Title of host publicationInternational Conference "Functional Materials and Nanotechnologies" (FM&NT-2011)
Subtitle of host publicationConference Proceedings
Publication statusPublished - 2011
EventInternational Conference "Functional Materials and Nanotechnologies" (FM&NT-2011) - Institute of Solid State Physics, University of Latvia, Riga, Latvia
Duration: 5 Apr 20118 Apr 2011

Publication series

NameIOP Conference Series: Materials Science and Engineering
PublisherIOP Publishing Ltd.
ISSN (Print)1757-8981


ConferenceInternational Conference "Functional Materials and Nanotechnologies" (FM&NT-2011)
Abbreviated titleFM&NT-2011
Internet address

Field of Science*

  • 2.5 Materials engineering
  • 2.6 Medical engineering
  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database


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