Tooth-Surface-Specific Effects of MI Varnish™: A 3-Year Randomized Clinical Trial

Jekaterīna Gudkina; Bennett T. Amaechi; Stephen H. Abrams; Anda Brinkmane

doi:10.3390/oral3030030

Tooth-Surface-Specific Effects of MI Varnish™: A 3-Year Randomized Clinical Trial

Jekaterīna Gudkina (Corresponding Author), Bennett T. Amaechi, Stephen H. Abrams, Anda Brinkmane

Department of Conservative Dentistry and Oral Health

Research output: Contribution to journal › Article › peer-review

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Abstract

Aim: Our previous three-year randomized control trial showed that the application of
MI Varnish™ (5% NaF/CPP-ACP) every 3 months reduced further caries development in 6- and
12-year-olds over a 3-year period. The purpose of this secondary analysis was to investigate whether
MI Varnish™ had a differential effect on cumulative caries increment on different tooth surfaces.
Methods: Group 1 (n = 48) (6-year-old children) and Group 3 (n = 47) (12-year-old children) received
quarterly varnish applications, while Group 2 (n = 48) (6-year-old children) and Group 4 (n = 37)
(12-year-old children) did not receive varnish applications. ICDAS caries scoring classified lesions
as non-cavitated (n/c) lesions (ICDAS 1 and 2), cavitated (c) lesions (ICDAS II 3–6), non-cavitated
lesions around restorations (CARn/c), and cavitated lesions around restorations (CARc). Thus,
‘decayed’ in DFS was calculated as (ICDAS 1–6 + CARn/c + CARc). The Chi-square test, Welch test
(paired-t test), risk ratio test, and Pearson correlation coefficient were used for statistical analysis
(α = 0.05). Results: After comparing baseline and 36-month data, in group 1, there was a significant
(p < 0.01) reduction in caries in occlusal (23.11%) and proximal (21.35%) surfaces and a non-significant
reduction in buccal/lingual surfaces (5.28%). In group 2, caries reduction was significant (p < 0.01)
in occlusal surfaces (38.52%) but non-significant in proximal (7.78%) and buccal/lingual (7.12%)
surfaces. In groups 3 and 4, significant (p < 0.001) increases in caries were observed in proximal
(36.03% (group 3)/54.30% (group 4)) and buccal/lingual surfaces (51.02% (group 3)/45.98% (group 4)),
and a non-significant increase was observed in occlusal surfaces (11.49% (group 3)/22.01% (group 4)).
The relative risk had increased by 4% only on proximal surfaces in 6-year-olds. Conclusions: the
application of MI Varnish™ every 3 months demonstrated a caries reduction effect on interproximal
and occlusal surfaces among 6- and 12-year-old children. (Trial registration ISRCTN10584414).

Original language	English
Pages (from-to)	372-388
Number of pages	16
Journal	Oral
Volume	3
Issue number	3
DOIs	https://doi.org/10.3390/oral3030030
Publication status	Published - 7 Aug 2023

Keywords*

caries increment
Hygiene habits
tooth surface effect
MI Varnish™

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.3390/oral3030030Licence: CC BY

Tooth-Surface-Specific EffectsFinal published version, 955 KBLicence: CC BY

Cite this

@article{ae6d6be8b54e444e8270fee8b67ce8f9,

title = "Tooth-Surface-Specific Effects of MI Varnish{\texttrademark}: A 3-Year Randomized Clinical Trial",

abstract = "Aim: Our previous three-year randomized control trial showed that the application ofMI Varnish{\texttrademark} (5% NaF/CPP-ACP) every 3 months reduced further caries development in 6- and12-year-olds over a 3-year period. The purpose of this secondary analysis was to investigate whetherMI Varnish{\texttrademark} had a differential effect on cumulative caries increment on different tooth surfaces.Methods: Group 1 (n = 48) (6-year-old children) and Group 3 (n = 47) (12-year-old children) receivedquarterly varnish applications, while Group 2 (n = 48) (6-year-old children) and Group 4 (n = 37)(12-year-old children) did not receive varnish applications. ICDAS caries scoring classified lesionsas non-cavitated (n/c) lesions (ICDAS 1 and 2), cavitated (c) lesions (ICDAS II 3–6), non-cavitatedlesions around restorations (CARn/c), and cavitated lesions around restorations (CARc). Thus,{\textquoteleft}decayed{\textquoteright} in DFS was calculated as (ICDAS 1–6 + CARn/c + CARc). The Chi-square test, Welch test(paired-t test), risk ratio test, and Pearson correlation coefficient were used for statistical analysis(α = 0.05). Results: After comparing baseline and 36-month data, in group 1, there was a significant(p < 0.01) reduction in caries in occlusal (23.11%) and proximal (21.35%) surfaces and a non-significantreduction in buccal/lingual surfaces (5.28%). In group 2, caries reduction was significant (p < 0.01)in occlusal surfaces (38.52%) but non-significant in proximal (7.78%) and buccal/lingual (7.12%)surfaces. In groups 3 and 4, significant (p < 0.001) increases in caries were observed in proximal(36.03% (group 3)/54.30% (group 4)) and buccal/lingual surfaces (51.02% (group 3)/45.98% (group 4)),and a non-significant increase was observed in occlusal surfaces (11.49% (group 3)/22.01% (group 4)).The relative risk had increased by 4% only on proximal surfaces in 6-year-olds. Conclusions: theapplication of MI Varnish{\texttrademark} every 3 months demonstrated a caries reduction effect on interproximaland occlusal surfaces among 6- and 12-year-old children. (Trial registration ISRCTN10584414).",

keywords = "caries increment, Hygiene habits, tooth surface effect, MI Varnish{\texttrademark}",

author = "Jekaterīna Gudkina and Amaechi, {Bennett T.} and Abrams, {Stephen H.} and Anda Brinkmane",

year = "2023",

month = aug,

day = "7",

doi = "10.3390/oral3030030",

language = "English",

volume = "3",

pages = "372--388",

journal = "Oral",

issn = "2673-6373",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "3",

}

TY - JOUR

T1 - Tooth-Surface-Specific Effects of MI Varnish™

T2 - A 3-Year Randomized Clinical Trial

AU - Gudkina, Jekaterīna

AU - Amaechi, Bennett T.

AU - Abrams, Stephen H.

AU - Brinkmane, Anda

PY - 2023/8/7

Y1 - 2023/8/7

N2 - Aim: Our previous three-year randomized control trial showed that the application ofMI Varnish™ (5% NaF/CPP-ACP) every 3 months reduced further caries development in 6- and12-year-olds over a 3-year period. The purpose of this secondary analysis was to investigate whetherMI Varnish™ had a differential effect on cumulative caries increment on different tooth surfaces.Methods: Group 1 (n = 48) (6-year-old children) and Group 3 (n = 47) (12-year-old children) receivedquarterly varnish applications, while Group 2 (n = 48) (6-year-old children) and Group 4 (n = 37)(12-year-old children) did not receive varnish applications. ICDAS caries scoring classified lesionsas non-cavitated (n/c) lesions (ICDAS 1 and 2), cavitated (c) lesions (ICDAS II 3–6), non-cavitatedlesions around restorations (CARn/c), and cavitated lesions around restorations (CARc). Thus,‘decayed’ in DFS was calculated as (ICDAS 1–6 + CARn/c + CARc). The Chi-square test, Welch test(paired-t test), risk ratio test, and Pearson correlation coefficient were used for statistical analysis(α = 0.05). Results: After comparing baseline and 36-month data, in group 1, there was a significant(p < 0.01) reduction in caries in occlusal (23.11%) and proximal (21.35%) surfaces and a non-significantreduction in buccal/lingual surfaces (5.28%). In group 2, caries reduction was significant (p < 0.01)in occlusal surfaces (38.52%) but non-significant in proximal (7.78%) and buccal/lingual (7.12%)surfaces. In groups 3 and 4, significant (p < 0.001) increases in caries were observed in proximal(36.03% (group 3)/54.30% (group 4)) and buccal/lingual surfaces (51.02% (group 3)/45.98% (group 4)),and a non-significant increase was observed in occlusal surfaces (11.49% (group 3)/22.01% (group 4)).The relative risk had increased by 4% only on proximal surfaces in 6-year-olds. Conclusions: theapplication of MI Varnish™ every 3 months demonstrated a caries reduction effect on interproximaland occlusal surfaces among 6- and 12-year-old children. (Trial registration ISRCTN10584414).

AB - Aim: Our previous three-year randomized control trial showed that the application ofMI Varnish™ (5% NaF/CPP-ACP) every 3 months reduced further caries development in 6- and12-year-olds over a 3-year period. The purpose of this secondary analysis was to investigate whetherMI Varnish™ had a differential effect on cumulative caries increment on different tooth surfaces.Methods: Group 1 (n = 48) (6-year-old children) and Group 3 (n = 47) (12-year-old children) receivedquarterly varnish applications, while Group 2 (n = 48) (6-year-old children) and Group 4 (n = 37)(12-year-old children) did not receive varnish applications. ICDAS caries scoring classified lesionsas non-cavitated (n/c) lesions (ICDAS 1 and 2), cavitated (c) lesions (ICDAS II 3–6), non-cavitatedlesions around restorations (CARn/c), and cavitated lesions around restorations (CARc). Thus,‘decayed’ in DFS was calculated as (ICDAS 1–6 + CARn/c + CARc). The Chi-square test, Welch test(paired-t test), risk ratio test, and Pearson correlation coefficient were used for statistical analysis(α = 0.05). Results: After comparing baseline and 36-month data, in group 1, there was a significant(p < 0.01) reduction in caries in occlusal (23.11%) and proximal (21.35%) surfaces and a non-significantreduction in buccal/lingual surfaces (5.28%). In group 2, caries reduction was significant (p < 0.01)in occlusal surfaces (38.52%) but non-significant in proximal (7.78%) and buccal/lingual (7.12%)surfaces. In groups 3 and 4, significant (p < 0.001) increases in caries were observed in proximal(36.03% (group 3)/54.30% (group 4)) and buccal/lingual surfaces (51.02% (group 3)/45.98% (group 4)),and a non-significant increase was observed in occlusal surfaces (11.49% (group 3)/22.01% (group 4)).The relative risk had increased by 4% only on proximal surfaces in 6-year-olds. Conclusions: theapplication of MI Varnish™ every 3 months demonstrated a caries reduction effect on interproximaland occlusal surfaces among 6- and 12-year-old children. (Trial registration ISRCTN10584414).

KW - caries increment

KW - Hygiene habits

KW - tooth surface effect

KW - MI Varnish™

UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:001269369200001

U2 - 10.3390/oral3030030

DO - 10.3390/oral3030030

M3 - Article

SN - 2673-6373

VL - 3

SP - 372

EP - 388

JO - Oral

JF - Oral

IS - 3

ER -

Tooth-Surface-Specific Effects of MI Varnish™: A 3-Year Randomized Clinical Trial

Abstract

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Field of Science*

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Research on Dentistry Described by a Researcher at Riga Stradins University [Tooth-Surface-Specific Effects of MI Varnish(TM): A 3-Year Randomized Clinical Trial]

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Tooth-Surface-Specific Effects of MI Varnish™: A 3-Year Randomized Clinical Trial

Abstract

Keywords*

Field of Science*

Publication Type*

Access to Document

Other files and links

Fingerprint

Press/Media

Research on Dentistry Described by a Researcher at Riga Stradins University [Tooth-Surface-Specific Effects of MI Varnish(TM): A 3-Year Randomized Clinical Trial]

Cite this