Abstract
The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D.
Original language | English |
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Pages (from-to) | 440-446 |
Number of pages | 7 |
Journal | Natural Product Research |
Volume | 35 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 2021 |
Externally published | Yes |
Keywords*
- deoxypumiliotoxin 193H
- in vivo studies
- stereoselectivity
- Total synthesis
Field of Science*
- 1.4 Chemical sciences
- 3.1 Basic medicine
Publication Type*
- 1.1. Scientific article indexed in Web of Science and/or Scopus database