Total synthesis and in vivo evaluation of 8-deoxypumiliotoxin 193H

Liga Zvejniece, Maija Dambrova, Gints Smits (Coresponding Author)

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The total synthesis of both the double bond isomers of indolizine alkaloid 8-deoxypumiliotoxin 193H has been accomplished. Both the double bond isomers Z-4 and E-4 induced convulsions and inhibited neuro-muscular activity at a dose of 25 mg/kg after intraperitoneal injection in mice. The lethal dose of Z-4 and E-4 was 100 mg/kg, indicating that 8-deoxypumiliotoxin 193H is 10-times less toxic than the known pumiliotoxin (+)-251 D.

Original languageEnglish
Pages (from-to)440-446
Number of pages7
JournalNatural Product Research
Volume35
Issue number3
DOIs
Publication statusPublished - Feb 2021
Externally publishedYes

Keywords

  • deoxypumiliotoxin 193H
  • in vivo studies
  • stereoselectivity
  • Total synthesis

Field of Science

  • 3.1 Basic medicine
  • 1.4 Chemical sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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