Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

Pierre Bourdely; Giorgio Anselmi; Kristīne Vaivode; Rodrigo Nalio Ramos; Yoann Missolo-Koussou; Sofia Hidalgo; Jimena Tosselo; Nicolas Nuñez; Wilfrid Richer; Anne Vincent-Salomon; Alka Saxena; Kristie Wood; Alvaro Lladser; Eliane Piaggio; Julie Helft; Pierre Guermonprez

doi:10.1016/j.immuni.2020.06.002

Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells

Pierre Bourdely
, Giorgio Anselmi
, Kristīne Vaivode
, Rodrigo Nalio Ramos
, Yoann Missolo-Koussou
, Sofia Hidalgo
, Jimena Tosselo
, Nicolas Nuñez
, Wilfrid Richer
, Anne Vincent-Salomon
, Alka Saxena
, Kristie Wood
, Alvaro Lladser
, Eliane Piaggio
, Julie Helft
, Pierre Guermonprez (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

281 Citations (Scopus)

Abstract

Bourdely et al. identify human CD88⁻CD1c⁺CD163⁺ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103⁺CD8⁺ T cells in vitro, and their infiltration correlates with CD8⁺CD69⁺CD103⁺ T_RM accumulation in breast tumors.

Original language	English
Pages (from-to)	335-352.e8
Journal	Immunity
Volume	53
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2020.06.002
Publication status	Published - 18 Aug 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords*

cDC2s
conventional DCs
DC progenitors
DC3s
inflammatory DCs
monocytes
mononuclear phagocytes
T

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.immuni.2020.06.002Licence: CC BY

Transcriptional and Functional AnalysisFinal published version, 7.06 MBLicence: CC BY

Cite this

Bourdely, P., Anselmi, G., Vaivode, K., Ramos, R. N., Missolo-Koussou, Y., Hidalgo, S., Tosselo, J., Nuñez, N., Richer, W., Vincent-Salomon, A., Saxena, A., Wood, K., Lladser, A., Piaggio, E., Helft, J., & Guermonprez, P. (2020). Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells. Immunity, 53(2), 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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title = "Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells",

abstract = "Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.",

keywords = "cDC2s, conventional DCs, DC progenitors, DC3s, inflammatory DCs, monocytes, mononuclear phagocytes, T",

author = "Pierre Bourdely and Giorgio Anselmi and Kristīne Vaivode and Ramos, \{Rodrigo Nalio\} and Yoann Missolo-Koussou and Sofia Hidalgo and Jimena Tosselo and Nicolas Nu{\~n}ez and Wilfrid Richer and Anne Vincent-Salomon and Alka Saxena and Kristie Wood and Alvaro Lladser and Eliane Piaggio and Julie Helft and Pierre Guermonprez",

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year = "2020",

month = aug,

day = "18",

doi = "10.1016/j.immuni.2020.06.002",

language = "English",

volume = "53",

pages = "335--352.e8",

journal = "Immunity",

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number = "2",

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Bourdely, P, Anselmi, G, Vaivode, K, Ramos, RN, Missolo-Koussou, Y, Hidalgo, S, Tosselo, J, Nuñez, N, Richer, W, Vincent-Salomon, A, Saxena, A, Wood, K, Lladser, A, Piaggio, E, Helft, J & Guermonprez, P 2020, 'Transcriptional and Functional Analysis of CD1c⁺ Human Dendritic Cells Identifies a CD163⁺ Subset Priming CD8⁺CD103⁺ T Cells', Immunity, vol. 53, no. 2, pp. 335-352.e8. https://doi.org/10.1016/j.immuni.2020.06.002

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T1 - Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells

AU - Bourdely, Pierre

AU - Anselmi, Giorgio

AU - Vaivode, Kristīne

AU - Ramos, Rodrigo Nalio

AU - Missolo-Koussou, Yoann

AU - Hidalgo, Sofia

AU - Tosselo, Jimena

AU - Nuñez, Nicolas

AU - Richer, Wilfrid

AU - Vincent-Salomon, Anne

AU - Saxena, Alka

AU - Wood, Kristie

AU - Lladser, Alvaro

AU - Piaggio, Eliane

AU - Helft, Julie

AU - Guermonprez, Pierre

PY - 2020/8/18

Y1 - 2020/8/18

N2 - Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.

AB - Bourdely et al. identify human CD88−CD1c+CD163+ DC3s as a pro-inflammatory phagocyte lineage sharing features with monocytes and conventional DCs. DC3s efficiently induce differentiation of CD103+CD8+ T cells in vitro, and their infiltration correlates with CD8+CD69+CD103+ TRM accumulation in breast tumors.

KW - cDC2s

KW - conventional DCs

KW - DC progenitors

KW - DC3s

KW - inflammatory DCs

KW - monocytes

KW - mononuclear phagocytes

KW - T

UR - https://www.scopus.com/pages/publications/85087942391

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DO - 10.1016/j.immuni.2020.06.002

M3 - Article

C2 - 32610077

AN - SCOPUS:85087942391

SN - 1074-7613

VL - 53

SP - 335-352.e8

JO - Immunity

JF - Immunity

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ER -