Translation and validation of the Myasthenia Gravis Activities of Daily Living Questionnaire: Latvian version

Arta Grosmane, Ieva Roze, Marija Roddate, Gundega Ķauķe, Violeta Žukova, Ieva Glāzere, Maksims Zolovs, Viktorija Ķēniņa (Corresponding Author)

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Abstract

INTRODUCTION: Our aim was to translate, adapt and validate the Myasthenia Gravis Activities of Daily Living scale into the Latvian language and to evaluate this instrument (MG-ADL-L) in terms of construct validity and reliability.

METHODS: We enrolled patients with a confirmed MG diagnosis, who could speak Latvian fluently. We performed translation and adaptation according to the cross-cultural adaptation guidelines for self-reported measures. The patients were evaluated by a physician according to the Myasthenia Gravis Foundation of America classification (MGFA) and using the Myasthenia Gravis Composite Score (MGCS). Patients were asked to complete the MG-ADL-L and the 15-item Myasthenia Gravis Quality of Life (MGQOL15) Internal consistency was evaluated based on Cronbach's α, reproducibility-Cohen's weighted kappa and construct validity-Spearman's correlation between the MG-ADL-L and the MGQOL15 and MGCS. We used the Kruskal-Wallis H test to compare the MG-ADL-L score distribution between the MGFA groups.

RESULTS: 38 enrolled patients in the study. There was an acceptable internal consistency (Cronbach's α = 0.76) and moderate to very good agreement between the test and retest scores (Cohen's weighted kappa = 0.54 and 0.81). The MG-ADL-L showed a moderate positive correlation with the MGQOL15 (r = 0.5, p  = 0.001) and the MGCS (r = 0.62, p  < 0.001). There was a significant difference in MG-ADL-L scores between the MGFA groups ( p  = 0.007).

DISCUSSION: The MG-ADL-L is a valid and reliable self-reported scale to assess and evaluate symptom severity and the impact of the disease on the lives of patients with MG.

Original languageEnglish
Article number1397603
Pages (from-to)01 -06
Number of pages6
JournalFrontiers in Neurology
Volume15
DOIs
Publication statusPublished - 27 May 2024

Keywords*

  • daily activities
  • MG-ADL
  • myasthenia gravis
  • scale
  • validation

Field of Science*

  • 3.2 Clinical medicine
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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