Treatment of skin oncological disease using an immusupressive medication

Ingmārs Mikažāns, Ilona Hartmane (Corresponding Author), Mihails Scerbuks, Iveta Ivdra, Ieva Saulite, Vanda Bondare-Ansberga , Artis Lapsins

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Abstract

Introduction: Skin cancer or non-melanoma
malignant formations, as well as melanomas, are
recorded in more than 2-3 million people every year.
The most important cause of the occurrence of this
disease is the effect of UV radiation on damaged
areas of the skin, birthmarks, or sensitive skin (light,
capable of burning). Dermatoscopy is one of the most
important methods for determining the stage of tumor
development, and the simplest method of treatment
in the initial stages is the use of immunosuppressive
agents that reduce the work of the immune system by
preventing the formation of antibodies.Objectives: The study aims to investigate the
correlation between immunosuppressive drug usage
and susceptibility to skin oncological diseases.
The study investigated the correlation between
immunosuppressive drug usage and susceptibility
to skin cancer, particularly melanoma. The specific
objectives involve assessing the influence of these
medications on melanoma risk, understanding
their effects on skin cancer treatment outcomes,
optimizing treatment approaches for reduced adverse
effects, uncovering the intricate interplay between
immune suppression and cancer management,
contextualizing findings within the framework of cancer
immunotherapy advancements, and revealing the
impact of immunosuppressive drugs on susceptibility
to rare cancers like Kaposi’s sarcoma. Methods: For
this study, it was taken a case of Kaposi’s sarcoma from an 82-year-old man. The patient took 122 doses of
the immunosuppressive drug Nivolumab for 2 weeks.
Results: After the end of the drug’s intake, the parts of
the gastrointestinal tract were examined, and as a result,
it was found that the patient recovered. When compared
with people who do not take immunosuppressive
drugs, there is a high risk of melanoma development;
moreover, the highest risk has been found in drugs
used to prevent the rejection of transplanted organs.
The negative effects of immunosuppressive drugs such
as immunosuppression and skin photosensitivity may
explain these results. These findings may help reduce
the risk of skin oncological disease through increased
surveillance and awareness and more careful sun
exposure for doctors and users of these drugs
Original languageEnglish
Pages (from-to)983-995
JournalGaceta Medica de Caracas
Volume131
Issue number4
DOIs
Publication statusPublished - Dec 2023

Keywords*

  • Pharmacokinetics
  • Kaposi’s sarcoma
  • corticosteroids
  • lysine cell syndrome
  • dermatosis
  • adenocarcinoma.

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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