Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis

Laura Ansone; Monta Ustinova; Anna Terentjeva; Ingus Pērkons; Līga Birzniece; Vita Rovīte; Baiba Rozentāle; Ludmila Vīksna; Oksana Koļesova; Kristaps Kļaviņš; Jānis Kloviņš

doi:10.1101/2021.03.31.21254699

Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis

Laura Ansone
, Monta Ustinova
, Anna Terentjeva
, Ingus Pērkons
, Līga Birzniece
, Vita Rovīte
, Baiba Rozentāle
, Ludmila Vīksna
, Oksana Koļesova
, Kristaps Kļaviņš
, Jānis Kloviņš^*

^*Corresponding author for this work

Rīga Stradiņš University

Research output: Working paper › Preprint

Original language	English
Publisher	medRxiv
Number of pages	16
DOIs	https://doi.org/10.1101/2021.03.31.21254699
Publication status	Published - Apr 2021

Keywords*

COVID-19

Field of Science

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

6. Other publications

Access to Document

10.1101/2021.03.31.21254699Licence: CC BY-NC

Clinical, biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with socio-demographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines
Vīksna, L. (Project leader), Leja, M. (Work package leader), Murovska, M. (Project leader), Gardovska, D. (Work package leader), Koļesova, O. (Member of project working group), Laivacuma, S. (Member of project working group), Platkājis, A. (Work package leader), Eglīte, J. (Work package leader), Šķesters, A. (Work package leader), Radziņa, M. (Member of project working group), Stūre, G. (Member of project working group), Zavadska, D. (Member of project working group), Storoženko, J. (Member of project working group), Rozentāle, B. (Member of project working group), Zeltiņa, I. (Member of project working group), Koļesovs, A. (Work package leader), Nora-Krūkle, Z. (Member of project working group), Grāvelsiņa, S. (Member of project working group), Karelis, G. (Member of project working group), Sperga, M. (Member of project working group), Plaudis, H. (Member of project working group), Arāja, D. (Member of project working group), Dzīvīte-Krišāne, I. (Member of project working group), Aleksejeva, E. (Member of project working group), Puķīte, I. (Member of project working group), Grantiņa, I. (Member of project working group), Ivanova, V. (Administrative manager), Ivanovs, A. (Member of project working group), Arutjuņana, S. (Member of project working group), Vanaga, I. (Member of project working group), Kustovs, D. (Member of project working group), Čistjakovs, M. (Member of project working group), Strojeva, S. (Member of project working group), Sokolovska, L. (Member of project working group), Meiere, A. (Member of project working group), Bajāre, L. (Member of project working group) & Vilmane, A. (Member of project working group)
Latvian Council of Science
1/07/20 → 30/06/21
Project: Research and development projects financed by the Latvian state budget › National Research Programme Projects

Cite this

Ansone, L., Ustinova, M., Terentjeva, A., Pērkons, I., Birzniece, L., Rovīte, V., Rozentāle, B., Vīksna, L., Koļesova, O., Kļaviņš, K., & Kloviņš, J. (2021). Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis. medRxiv. https://doi.org/10.1101/2021.03.31.21254699

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keywords = "COVID-19",

author = "Laura Ansone and Monta Ustinova and Anna Terentjeva and Ingus Pērkons and Līga Birzniece and Vita Rovīte and Baiba Rozentāle and Ludmila Vīksna and Oksana Koļesova and Kristaps Kļaviņ{\v s} and Jānis Kloviņ{\v s}",

year = "2021",

month = apr,

doi = "10.1101/2021.03.31.21254699",

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Ansone, L, Ustinova, M, Terentjeva, A, Pērkons, I, Birzniece, L, Rovīte, V, Rozentāle, B , Vīksna, L , Koļesova, O, Kļaviņš, K & Kloviņš, J 2021 'Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis' medRxiv. https://doi.org/10.1101/2021.03.31.21254699

TY - UNPB

T1 - Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis

AU - Ansone, Laura

AU - Ustinova, Monta

AU - Terentjeva, Anna

AU - Pērkons, Ingus

AU - Birzniece, Līga

AU - Rovīte, Vita

AU - Rozentāle, Baiba

AU - Vīksna, Ludmila

AU - Koļesova, Oksana

AU - Kļaviņš, Kristaps

AU - Kloviņš, Jānis

PY - 2021/4

Y1 - 2021/4

KW - COVID-19

U2 - 10.1101/2021.03.31.21254699

DO - 10.1101/2021.03.31.21254699

M3 - Preprint

BT - Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis

PB - medRxiv

ER -

Tryptophan and arginine metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics analysis

Keywords*

Field of Science

Publication Type*

Access to Document

Projects

Clinical, biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with socio-demographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines

Cite this