Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Nataliia Sergeevna Novikova; Anastasiia Sergeevna Diatlova; Kristina Zurabovna Derevtsova; Elena Andreevna Korneva; Tamara Viktorovna Fedotkina; Yuri Ostrinki; Lital Abraham; Shir Quinn; Yahel Segal; Leonid Churilov; Miri Blank; Yehuda Shoenfeld; Rina Aharoni; Howard Amital

doi:10.1016/j.jneuroim.2019.577070

Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Nataliia Sergeevna Novikova
, Anastasiia Sergeevna Diatlova
, Kristina Zurabovna Derevtsova
, Elena Andreevna Korneva
, Tamara Viktorovna Fedotkina
, Yuri Ostrinki
, Lital Abraham
, Shir Quinn
, Yahel Segal
, Leonid Churilov
, Miri Blank
, Yehuda Shoenfeld
, Rina Aharoni
, Howard Amital (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

Original language	English
Article number	577070
Journal	Journal of Neuroimmunology
Volume	337
DOIs	https://doi.org/10.1016/j.jneuroim.2019.577070
Publication status	Published - 15 Dec 2019
Externally published	Yes

Keywords*

Autoimmunity
Experimental autoimmune encephalomyelitis
Multiple sclerosis
Tuftsin-phosphorylcholine

Field of Science*

3.2 Clinical medicine
3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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10.1016/j.jneuroim.2019.577070

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Novikova, N. S., Diatlova, A. S., Derevtsova, K. Z., Korneva, E. A., Fedotkina, T. V., Ostrinki, Y., Abraham, L., Quinn, S., Segal, Y., Churilov, L., Blank, M., Shoenfeld, Y., Aharoni, R., & Amital, H. (2019). Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis. Journal of Neuroimmunology, 337, Article 577070. https://doi.org/10.1016/j.jneuroim.2019.577070

@article{0cd32d9ab30044b280913e176b8cdf37,

title = "Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis",

abstract = "Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.",

keywords = "Autoimmunity, Experimental autoimmune encephalomyelitis, Multiple sclerosis, Tuftsin-phosphorylcholine",

author = "Novikova, \{Nataliia Sergeevna\} and Diatlova, \{Anastasiia Sergeevna\} and Derevtsova, \{Kristina Zurabovna\} and Korneva, \{Elena Andreevna\} and Fedotkina, \{Tamara Viktorovna\} and Yuri Ostrinki and Lital Abraham and Shir Quinn and Yahel Segal and Leonid Churilov and Miri Blank and Yehuda Shoenfeld and Rina Aharoni and Howard Amital",

note = "Publisher Copyright: {\textcopyright} 2019",

year = "2019",

month = dec,

day = "15",

doi = "10.1016/j.jneuroim.2019.577070",

language = "English",

volume = "337",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

AU - Novikova, Nataliia Sergeevna

AU - Diatlova, Anastasiia Sergeevna

AU - Derevtsova, Kristina Zurabovna

AU - Korneva, Elena Andreevna

AU - Fedotkina, Tamara Viktorovna

AU - Ostrinki, Yuri

AU - Abraham, Lital

AU - Quinn, Shir

AU - Segal, Yahel

AU - Churilov, Leonid

AU - Blank, Miri

AU - Shoenfeld, Yehuda

AU - Aharoni, Rina

AU - Amital, Howard

PY - 2019/12/15

Y1 - 2019/12/15

N2 - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

AB - Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS) which carries a significant burden of morbidity and mortality. Herein we examine the effects of acute treatment with tuftsin-phosphorylcholine (TPC), a novel immune-modulating helminth derived compound, on a murine model of MS. Experimental autoimmune encephalomyelitis (EAE) mice received acute treatment with TPC showed an improved clinical score and significantly less signs of inflammation and demyelination in CNS tissue compared with vehicle treated EAE mice. Our findings suggest that TPC may provide a beneficial clinical effect in EAE and may therefore have a potential value for ameliorating clinical manifestations and delaying disease progression in MS.

KW - Autoimmunity

KW - Experimental autoimmune encephalomyelitis

KW - Multiple sclerosis

KW - Tuftsin-phosphorylcholine

UR - https://www.scopus.com/pages/publications/85074187367

U2 - 10.1016/j.jneuroim.2019.577070

DO - 10.1016/j.jneuroim.2019.577070

M3 - Article

C2 - 31683117

AN - SCOPUS:85074187367

SN - 0165-5728

VL - 337

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577070

ER -

Tuftsin-phosphorylcholine attenuate experimental autoimmune encephalomyelitis

Abstract

Keywords*

Field of Science*

Publication Type*

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