Ultrastructural characteristics of tissue response after implantation of calcium phosphate ceramics in the mandible of rabbit

V. Zalite, V. Groma, D. Jakovlevs, J. Locs, G. Salms

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

This study is undertaken in order to explore interaction between calcium phosphate bioceramics and surrounding tissues in the mandible of rabbit. The tissue response was evaluated 6 months after implantation of ceramics. Three kinds of porous bioceramics were studied: hydroxyapatite (HAp) and HAp mixture with β-tricalcium phosphate (95%HAp/5%β-TCP and 80%HAp/20%β-TCP). X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM) were used to characterize porous bioceramic samples. Transmission electron microscopy (TEM), light microscopy and SEM examinations were applied for evaluation of interaction between tissues and bioceramics. The open porosity of obtained samples is in range between 50 to 60%. Pores have not specific form and mainly they are interconnected. The histological studies demonstrated appearance of a thick fibrous collagenous capsule formed around the pure HAp and presented by densely packed fibers and flattened fibrocytes, while addition of b-TCP evidenced highly vascularized adipose tissue.

Original languageEnglish
Title of host publicationInternational Symposium on Biomedical Engineering and Medical Physics, ISBEMP 2012
PublisherSpringer Nature Switzerland AG
Pages194-197
Number of pages4
ISBN (Print)9783642341960
DOIs
Publication statusPublished - 2013
EventInternational Symposium on Biomedical Engineering and Medical Physics - Riga, Latvia
Duration: 10 Oct 201212 Oct 2012

Publication series

NameIFMBE Proceedings
Volume38 IFMBE
ISSN (Print)1680-0737

Symposium

SymposiumInternational Symposium on Biomedical Engineering and Medical Physics
Abbreviated titleISBEMP 2012
Country/TerritoryLatvia
CityRiga
Period10/10/1212/10/12

Keywords

  • β-tricalcium phosphate
  • cell
  • ceramics
  • hydroxyapatite
  • microstructure
  • porous structure
  • tissue

Field of Science

  • 2.6 Medical engineering
  • 3.1 Basic medicine

Publication Type

  • 3.1. Articles or chapters in proceedings/scientific books indexed in Web of Science and/or Scopus database

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