Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Sophie Steiner; Annick Fehrer; Friederike Hoheisel; Simon Schoening; Anna Aschenbrenner; Nina Babel; Judith Bellmann-Strobl; Carsten Finke; Øystein Fluge; Laura Froehlich; Andreas Goebel; Bettina Grande; Johannes Peter Haas; Bettina Hohberger; Leonard A. Jason; Anthony L. Komaroff; Eliana Lacerda; Max Liebl; Andrea Maier; Olav Mella; Luis Nacul; Friedemann Paul; Bhupesh K. Prusty; Christian Puta; Gabriela Riemekasten; Wolfgang Ries; Peter C. Rowe; Birgit Sawitzki; Yehuda Shoenfeld; Joachim L. Schultze; Martina Seifert; Nuno Sepúlveda; Franziska Sotzny; Elisa Stein; Michael Stingl; Friederike Ufer; Christian Veauthier; Francisco Westermeier; Klaus Wirth; Bernd Wolfarth; Pawel Zalewski; Uta Behrends; Carmen Scheibenbogen

doi:10.1016/j.autrev.2023.103452

Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Sophie Steiner, Annick Fehrer, Friederike Hoheisel (Corresponding Author), Simon Schoening, Anna Aschenbrenner, Nina Babel, Judith Bellmann-Strobl, Carsten Finke, Øystein Fluge, Laura Froehlich, Andreas Goebel, Bettina Grande, Johannes Peter Haas, Bettina Hohberger, Leonard A. Jason, Anthony L. Komaroff, Eliana Lacerda, Max Liebl, Andrea Maier, Olav MellaLuis Nacul, Friedemann Paul, Bhupesh K. Prusty, Christian Puta, Gabriela Riemekasten, Wolfgang Ries, Peter C. Rowe, Birgit Sawitzki, Yehuda Shoenfeld, Joachim L. Schultze, Martina Seifert, Nuno Sepúlveda, Franziska Sotzny, Elisa Stein, Michael Stingl, Friederike Ufer, Christian Veauthier, Francisco Westermeier, Klaus Wirth, Bernd Wolfarth, Pawel Zalewski, Uta Behrends, Carmen Scheibenbogen

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

Original language	English
Article number	103452
Number of pages	8
Journal	Autoimmunity Reviews
Volume	22
Issue number	11
DOIs	https://doi.org/10.1016/j.autrev.2023.103452
Publication status	Published - Nov 2023
Externally published	Yes

Keywords*

Coronavirus disease 2019 (COVID-19)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)
Post-COVID fatigue (PCF)
Post-COVID syndrome (PCS)
Severe acute respiratory syndrome 2 (SARS-CoV-2)

Field of Science*

3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1016/j.autrev.2023.103452Licence: CC BY

Cite this

Steiner, S., Fehrer, A., Hoheisel, F., Schoening, S., Aschenbrenner, A., Babel, N., Bellmann-Strobl, J., Finke, C., Fluge, Ø., Froehlich, L., Goebel, A., Grande, B., Haas, J. P., Hohberger, B., Jason, L. A., Komaroff, A. L., Lacerda, E., Liebl, M., Maier, A., ... Scheibenbogen, C. (2023). Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. Autoimmunity Reviews, 22(11), Article 103452. https://doi.org/10.1016/j.autrev.2023.103452

@article{5e586f3b06e14bf998a04292e939fd73,

title = "Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charit{\'e} Fatigue Center",

abstract = "Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charit{\'e} Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.",

keywords = "Coronavirus disease 2019 (COVID-19), Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), Post-COVID fatigue (PCF), Post-COVID syndrome (PCS), Severe acute respiratory syndrome 2 (SARS-CoV-2)",

author = "Sophie Steiner and Annick Fehrer and Friederike Hoheisel and Simon Schoening and Anna Aschenbrenner and Nina Babel and Judith Bellmann-Strobl and Carsten Finke and {\O}ystein Fluge and Laura Froehlich and Andreas Goebel and Bettina Grande and Haas, {Johannes Peter} and Bettina Hohberger and Jason, {Leonard A.} and Komaroff, {Anthony L.} and Eliana Lacerda and Max Liebl and Andrea Maier and Olav Mella and Luis Nacul and Friedemann Paul and Prusty, {Bhupesh K.} and Christian Puta and Gabriela Riemekasten and Wolfgang Ries and Rowe, {Peter C.} and Birgit Sawitzki and Yehuda Shoenfeld and Schultze, {Joachim L.} and Martina Seifert and Nuno Sep{\'u}lveda and Franziska Sotzny and Elisa Stein and Michael Stingl and Friederike Ufer and Christian Veauthier and Francisco Westermeier and Klaus Wirth and Bernd Wolfarth and Pawel Zalewski and Uta Behrends and Carmen Scheibenbogen",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

doi = "10.1016/j.autrev.2023.103452",

language = "English",

volume = "22",

journal = "Autoimmunity Reviews",

issn = "1568-9972",

publisher = "Elsevier B.V.",

number = "11",

}

Steiner, S, Fehrer, A, Hoheisel, F, Schoening, S, Aschenbrenner, A, Babel, N, Bellmann-Strobl, J, Finke, C, Fluge, Ø, Froehlich, L, Goebel, A, Grande, B, Haas, JP, Hohberger, B, Jason, LA, Komaroff, AL, Lacerda, E, Liebl, M, Maier, A, Mella, O, Nacul, L, Paul, F, Prusty, BK, Puta, C, Riemekasten, G, Ries, W, Rowe, PC, Sawitzki, B, Shoenfeld, Y, Schultze, JL, Seifert, M, Sepúlveda, N, Sotzny, F, Stein, E, Stingl, M, Ufer, F, Veauthier, C, Westermeier, F, Wirth, K, Wolfarth, B, Zalewski, P, Behrends, U & Scheibenbogen, C 2023, 'Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center', Autoimmunity Reviews, vol. 22, no. 11, 103452. https://doi.org/10.1016/j.autrev.2023.103452

Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center. / Steiner, Sophie; Fehrer, Annick; Hoheisel, Friederike (Corresponding Author) et al.
In: Autoimmunity Reviews, Vol. 22, No. 11, 103452, 11.2023.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art

T2 - Report of the 2nd international meeting at the Charité Fatigue Center

AU - Steiner, Sophie

AU - Fehrer, Annick

AU - Hoheisel, Friederike

AU - Schoening, Simon

AU - Aschenbrenner, Anna

AU - Babel, Nina

AU - Bellmann-Strobl, Judith

AU - Finke, Carsten

AU - Fluge, Øystein

AU - Froehlich, Laura

AU - Goebel, Andreas

AU - Grande, Bettina

AU - Haas, Johannes Peter

AU - Hohberger, Bettina

AU - Jason, Leonard A.

AU - Komaroff, Anthony L.

AU - Lacerda, Eliana

AU - Liebl, Max

AU - Maier, Andrea

AU - Mella, Olav

AU - Nacul, Luis

AU - Paul, Friedemann

AU - Prusty, Bhupesh K.

AU - Puta, Christian

AU - Riemekasten, Gabriela

AU - Ries, Wolfgang

AU - Rowe, Peter C.

AU - Sawitzki, Birgit

AU - Shoenfeld, Yehuda

AU - Schultze, Joachim L.

AU - Seifert, Martina

AU - Sepúlveda, Nuno

AU - Sotzny, Franziska

AU - Stein, Elisa

AU - Stingl, Michael

AU - Ufer, Friederike

AU - Veauthier, Christian

AU - Westermeier, Francisco

AU - Wirth, Klaus

AU - Wolfarth, Bernd

AU - Zalewski, Pawel

AU - Behrends, Uta

AU - Scheibenbogen, Carmen

PY - 2023/11

Y1 - 2023/11

N2 - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

AB - Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a devastating disease affecting millions of people worldwide. Due to the 2019 pandemic of coronavirus disease (COVID-19), we are facing a significant increase of ME/CFS prevalence. On May 11th to 12th, 2023, the second international ME/CFS conference of the Charité Fatigue Center was held in Berlin, Germany, focusing on pathomechanisms, diagnosis, and treatment. During the two-day conference, more than 100 researchers from various research fields met on-site and over 700 attendees participated online to discuss the state of the art and novel findings in this field. Key topics from the conference included: the role of the immune system, dysfunction of endothelial and autonomic nervous system, and viral reactivation. Furthermore, there were presentations on innovative diagnostic measures and assessments for this complex disease, cutting-edge treatment approaches, and clinical studies. Despite the increased public attention due to the COVID-19 pandemic, the subsequent rise of Long COVID-19 cases, and the rise of funding opportunities to unravel the pathomechanisms underlying ME/CFS, this severe disease remains highly underresearched. Future adequately funded research efforts are needed to further explore the disease etiology and to identify diagnostic markers and targeted therapies.

KW - Coronavirus disease 2019 (COVID-19)

KW - Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)

KW - Post-COVID fatigue (PCF)

KW - Post-COVID syndrome (PCS)

KW - Severe acute respiratory syndrome 2 (SARS-CoV-2)

UR - http://www.scopus.com/inward/record.url?scp=85173184115&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2023.103452

DO - 10.1016/j.autrev.2023.103452

M3 - Review article

C2 - 37742748

AN - SCOPUS:85173184115

SN - 1568-9972

VL - 22

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

IS - 11

M1 - 103452

ER -

Understanding, diagnosing, and treating Myalgic encephalomyelitis / chronic fatigue syndrome – State of the art: Report of the 2nd international meeting at the Charité Fatigue Center

Abstract

Keywords*

Field of Science*

Publication Type*

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