TY - JOUR
T1 - Urethane dimethacrylate based photopolymerizable resins for stereolithography 3D printing
T2 - A physicochemical characterisation and biocompatibility evaluation
AU - Pitzanti, Giulia
AU - Mohylyuk, Valentyn
AU - Corduas, Francesca
AU - Byrne, Niall M.
AU - Coulter, Jonathan A.
AU - Lamprou, Dimitrios A.
N1 - Funding Information:
The authors would like to thank Queen’s University of Belfast and the Engineering and Physical Sciences Research Council (EPSRC) for funding this work.
Publisher Copyright:
© 2023, The Author(s).
PY - 2023/7/15
Y1 - 2023/7/15
N2 - Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate photocurable resins based on urethane dimethacrylate (UDMA) combined with three different difunctional methacrylic diluents named ethylene glycol dimethacrylate (EGDMA), di(ethylene glycol) dimethacrylate (DEGDMA) or tri(ethylene glycol) dimethacrylate (TEGDMA). The resins were tested for viscosity, thermal behaviour and printability. After printing, the 3D printed specimens were measured with a digital calliper in order to investigate their accuracy to the digital model and tested with FT-IR, TGA and DSC. Their mechanical properties, contact angle, water sorption and biocompatibility were also evaluated. The photopolymerizable formulations investigated in this work achieved promising properties so as to be suitable for tissue engineering and other biomedical applications. Graphical abstract: [Figure not available: see fulltext.].
AB - Vat photopolymerisation (VP) three-dimensional printing (3DP) has attracted great attention in many different fields, such as electronics, pharmaceuticals, biomedical devices and tissue engineering. Due to the low availability of biocompatible photocurable resins, its application in the healthcare sector is still limited. In this work, we formulate photocurable resins based on urethane dimethacrylate (UDMA) combined with three different difunctional methacrylic diluents named ethylene glycol dimethacrylate (EGDMA), di(ethylene glycol) dimethacrylate (DEGDMA) or tri(ethylene glycol) dimethacrylate (TEGDMA). The resins were tested for viscosity, thermal behaviour and printability. After printing, the 3D printed specimens were measured with a digital calliper in order to investigate their accuracy to the digital model and tested with FT-IR, TGA and DSC. Their mechanical properties, contact angle, water sorption and biocompatibility were also evaluated. The photopolymerizable formulations investigated in this work achieved promising properties so as to be suitable for tissue engineering and other biomedical applications. Graphical abstract: [Figure not available: see fulltext.].
KW - 3D printing
KW - photopolymerization
KW - SLA
KW - UV-light curing inks
KW - dimethacrylate
KW - biomedical applications
UR - https://pubmed.ncbi.nlm.nih.gov/37454029/
UR - http://www.scopus.com/inward/record.url?scp=85164944687&partnerID=8YFLogxK
U2 - 10.1007/s13346-023-01391-y
DO - 10.1007/s13346-023-01391-y
M3 - Article
SN - 2190-393X
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
ER -