Use of a fluorescent probe to study the adrenoreceptive function of human erythrocytes

V. M. Sominskii, R. K. Bluma, I. E. Kalninya

Research output: Contribution to journalArticlepeer-review

Abstract

The authors have studied the possibility of using the fluorescent probe 4-(p-dimethyl aminostyryl)-1-methylpyridinium (DSM) for observing the interaction of β-adreno-active substances (adrenaline and propranolol) with specific human erythrocyte (E) receptors. Two types of binding of DSM to the E membranes have been identified - specific and unspecific. It has been established that DSM selectively reacts to preliminary treatment with β-adreno-active substances; the agonist adrenaline raises and the antagonist propranolol reduce the binding of the probe to the erythrocyte membrane. It is concluded that the DSM probe may be used to study the β adrenoreceptor function of the cell membranes.

Original languageEnglish
Pages (from-to)699-702
Number of pages4
JournalBiophysics
Volume30
Issue number4
Publication statusPublished - 1985
Externally publishedYes

Field of Science

  • 3.1 Basic medicine
  • 1.6 Biological sciences

Publication Type

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

Fingerprint

Dive into the research topics of 'Use of a fluorescent probe to study the adrenoreceptive function of human erythrocytes'. Together they form a unique fingerprint.

Cite this