Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience

Ilona Hartmane; Iveta Ivdra; Ingmārs Mikažāns; Aleksejs Princevs; Irēna Teterina; Vanda Bondare-Ansberga; Lelde Reinberga

doi:10.1177/09564624231206845

Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience

Ilona Hartmane (Corresponding Author), Iveta Ivdra, Ingmārs Mikažāns, Aleksejs Princevs, Irēna Teterina, Vanda Bondare-Ansberga , Lelde Reinberga

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy.
METHODS: A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted.
RESULTS: No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14months ± 2.76, and for latent forms, it was 7.52months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported.
CONCLUSIONS: Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.

Original language	English
Pages (from-to)	130-135
Number of pages	6
Journal	International Journal of STD and AIDS
Volume	35
Issue number	2
DOIs	https://doi.org/10.1177/09564624231206845
Publication status	Published - Feb 2024

Keywords*

syphilis
antibiotic
pregnancy
treatment

Field of Science*

3.1 Basic medicine
3.2 Clinical medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1177/09564624231206845

https://journals.sagepub.com/doi/10.1177/09564624231206845

Cite this

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title = "Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience",

abstract = "BACKGROUND: There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy.METHODS: A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted.RESULTS: No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14months ± 2.76, and for latent forms, it was 7.52months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported.CONCLUSIONS: Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.",

keywords = "syphilis, antibiotic, pregnancy, treatment",

author = "Ilona Hartmane and Iveta Ivdra and Ingmārs Mika{\v z}āns and Aleksejs Princevs and Irēna Teterina and Vanda Bondare-Ansberga and Lelde Reinberga",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2023.",

year = "2024",

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doi = "10.1177/09564624231206845",

language = "English",

volume = "35",

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TY - JOUR

T1 - Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience

AU - Hartmane, Ilona

AU - Ivdra, Iveta

AU - Mikažāns, Ingmārs

AU - Princevs, Aleksejs

AU - Teterina, Irēna

AU - Bondare-Ansberga , Vanda

AU - Reinberga, Lelde

N1 - Publisher Copyright: © The Author(s) 2023.

PY - 2024/2

Y1 - 2024/2

N2 - BACKGROUND: There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy.METHODS: A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted.RESULTS: No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14months ± 2.76, and for latent forms, it was 7.52months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported.CONCLUSIONS: Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.

AB - BACKGROUND: There are few data on the use of ceftriaxone in pregnant women diagnosed with syphilis. The aim of this study was to investigate the safety and efficacy of ceftriaxone as an alternative treatment option for syphilis during pregnancy.METHODS: A retrospective analysis of 79 pregnant women diagnosed with syphilis and treated with ceftriaxone was conducted.RESULTS: No cases of intolerance, Jarisch-Herxheimer reactions, or allergic reactions were recorded. The average time to seronegativation for secondary syphilis with symptoms was 6.14months ± 2.76, and for latent forms, it was 7.52months ± 1.84. Patients received no additional treatment. No serious adverse drug reactions were reported.CONCLUSIONS: Data from our study support the use of ceftriaxone as an effective and safe alternative treatment for pregnant women diagnosed with syphilis when penicillin therapy is contraindicated or unavailable.

KW - syphilis

KW - antibiotic

KW - pregnancy

KW - treatment

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U2 - 10.1177/09564624231206845

DO - 10.1177/09564624231206845

M3 - Article

SN - 0956-4624

VL - 35

SP - 130

EP - 135

JO - International Journal of STD and AIDS

JF - International Journal of STD and AIDS

IS - 2

ER -

Use of ceftriaxone as an alternative treatment method in pregnant women diagnosed with syphilis – a single centre experience

Abstract

Keywords*

Field of Science*

Publication Type*

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