Visualization of the Intracranial Pressure and Time Burden in Childhood Brain Trauma: What We Have Learned One Decade on With KidsBrainIT

Bavo Kempen, Bart Depreitere (Corresponding Author), Ian Piper, Juan Sahuquillo, Stefan Mircea Iencean, Hari Krishnan Kanthimathinathan, Julian Zipfel, Arta Barzdina, Stefano Pezzato, Patricia A Jones, Tsz-Yan Milly M Lo (Corresponding Author)

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

To validate the intracranial pressure (ICP) dose-response visualization plot for the first time in a novel prospectively collected pediatric traumatic brain injury (pTBI) data set from the multi-center multi-national KidsBrainIT consortium. Prospectively collected minute-by-minute ICP and mean arterial blood pressure time series of 104 pTBI patients were categorized in ICP intensity-duration episodes. These episodes were correlated with the 6-month Glasgow Outcome Score (GOS) and displayed in a color-coded ICP dose-response plot. The influence of cerebrovascular reactivity and cerebral perfusion pressure (CPP) were investigated. The generated ICP dose-response plot on the novel data set was similar to the previously published pediatric plot. This study confirmed that higher ICP episodes were tolerated for a shorter duration of time, with an approximately exponential decay curve delineating the positive and negative association zones. ICP above 20 mmHg for any duration in time was associated with poor outcome in our patients. Cerebrovascular reactivity state did not influence their respective transition curves above 10 mmHg ICP. CPP below 50 mmHg was not tolerated, regardless of ICP and duration, and was associated with worse outcome. The ICP dose-response plot was reproduced in a novel and independent pTBI data set. ICP above 20 mmHg and CPP below 50 mmHg for any duration in time were associated with worse outcome. This highlighted a pressing need to reduce pediatric ICP therapeutic thresholds used at the bedside.

Original languageEnglish
Pages (from-to)e1651-e1659
Number of pages9
JournalJournal of Neurotrauma
Volume41
Issue number13-14
DOIs
Publication statusPublished - 1 Jul 2024
Externally publishedYes

Field of Science*

  • 3.2 Clinical medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database

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