Vitamin D concentration, anthropometic and hormonal changes in male patients with and without teratozoospermia

Eliza Finka, Juris Erenpreiss, Violeta Fodina, Natalija Vedmedovska

Research output: Contribution to journalMeeting Abstractpeer-review


Teratozoospermia tends to be more common in male patients with obesity, age over 45 years, varicocele, and hormonal pathologies. Little is known about the vitamin D effect on sperm morphology.
The objective of this research is to determine vitamin D concentration in male patients with and without teratozoospermia and the association of its deficiency with different sperms variables.
The retrospective cross-sectional study was held by collecting the Infertility Treatment clinic’s medical records of patients with and without teratozoospermia. Vitamin D concentration, anthropometric and hormonal changes were analyzed in 152 male patients. Vitamin D insufficiency was defined as 25(OH)D level in serum < 30ng/mL. For the statistical analyse Mann-Whitney U, Kolmogorov-Smirnov, and T-test were used.
The patients from 18 to 46 years with teratozoospermia (study group=76) and without teratozoospermia (control group=76) were included in the study.
Interventions are not applicable.
Main outcome measures
Anthropometric data (age, height, weight, body mass index), hormonal data (thyroid stimulating hormone (TSH), testosterone, follicle-stimulating hormone (FSH), luteinizing hormone (LH) were compared in the male with teratozoospermia and normal sperm. The level of vitamin D was detected in both groups and semen parameters (count in ejaculate, sperm pH, motility, concentration and morphology) in subgroups with D vitamin deficiency and normal levels were investigated.
There was no statistical difference between the groups regarding age (p=0.94) and BMI (p=0.09). Vitamin D deficiency was statistically more often detected in patients with teratozoospermia comparing to controls (61.8% vs 38.2%, p<0.001). Among the patients with vitamin D deficiency defective sperm tails were confirmed statistically more often (p<0.001). There was no statistical difference between the subgroups in respect to FSH (p=0.9), LH (p=0.49), and TSH levels (p=0.05). Varicocele was diagnosed more often in patients with vitamin D deficiency (15.7% vs. 6.4%), approaching borderline statistical significance (p=0.07). Conclusions
This study confirmed the important role of vitamin D on male fertility, particularly, its effect on sperm morphology. Adequate Vitamin D levels should be attained in cases of fertility treatment, especially in the regions where vitamin D deficiency is common.
Original languageEnglish
Pages (from-to)185
JournalEuropean Gynecology and Obstetrics
Issue numberSuppl.1
Publication statusPublished - Nov 2021
Event14th Congress of the European Society of Gynecology - Online, Venice, Italy
Duration: 10 Nov 202113 Nov 2021
Conference number: 14

Field of Science*

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type*

  • 3.4. Other publications in conference proceedings (including local)


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