Wild-Grown and Cultivated Glechoma hederacea L. Chemical Composition and Potential for Cultivation in Organic Farming Conditions

Inga Sile (Coresponding Author), Valerija Krizhanovska, Ilva Nakurte, Ieva Mezaka, Laura Kalane, Jevgenijs Filipovs, Alekss Vecvanags, Osvalds Pugovics, Solveiga Grinberga, Maija Dambrova, Arta Kronberga

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)
1 Downloads (Pure)


Glechoma hederacea L. is a medicinal plant that is known in traditional medicine for its anti-inflammatory, antibacterial, antiviral, and anticancer properties. This study evaluated the potential for commercial production of G. hederacea and compared the chemical composition and activity of 70% ethanol extracts and steam-distilled essential oils from wild-grown and cultivated G. hederacea collected in different harvesting periods. The main compounds identified in the 70% ethanol extracts were phenolic acids (chlorogenic and rosmarinic acids) and flavonoid O-glycosides. The essential oil varied in the three accessions in the range of 0.32-2.98 mL/kg -1 of dry weight. The extracts possessed potent antioxidant and anti-inflammatory properties in LPS-treated bone-marrow-derived macrophages. The results of flow cytometry show that extracts from different vegetation periods reduced the conversion of macrophages to the proinflammatory phenotype M1. The chemical composition varied the most with the different harvesting periods, and the most suitable periods were the flowering and vegetative phases for the polyphenolic compounds and essential oils, respectively. G. hederacea can be successfully grown under organic farming conditions, and cultivation does not significantly affect the chemical composition and biological activity compared to wild-grown plants.

Original languageEnglish
Article number819
Issue number6
Publication statusPublished - 1 Mar 2022


  • Chemical composition
  • Cultivation
  • Essential oils
  • Glechoma hederacea
  • Harvesting period

Field of Science*

  • 1.6 Biological sciences
  • 3.1 Basic medicine

Publication Type*

  • 1.1. Scientific article indexed in Web of Science and/or Scopus database


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