Worldwide Disease — Haemorrhoids. How much do we know?

Inese Fišere (Coresponding Author), Valērija Groma, Niks Ričards Goldiņš, Andris Gardovskis, Jānis Gardovskis

Research output: Contribution to journalArticlepeer-review

Abstract

Haemorrhoids are highly vascular cushions of connective tissue in the anal canal, which are normal structures of the human body. Haemorrhoidal disease in clinical practice means that there is an abnormal enlargement of the anal cushions when these transform into “anal nodules”, bleed and/or prolapse. Haemorrhoidal disease is very common. Despite numerous studies undertaken and knowledge accumulated on the aetiology and pathogenesis of haemorrhoidal disease in the last decade, the specific mechanisms responsible for the development of the disease are not thoroughly understood. The pathophysiology is most likely multifactorial and complex, manifested by muscle weakness, intrarectal prolapse, changes in vascular pressure and flow in blood vessels, malformations, sphincter damage and failure, venostasis, inflammatory reactions, endothelin and collagen abnormalities, matrix metalloproteinases activity, etc. Currently, treatment guidelines for the haemorrhoidal disease are based on Goligher's classification. The classification of haemorrhoidal disease should be submitted to revision by including aetiological factors, the dynamism of prolapse, symptomatology, enteropathogenesis, and gender characteristics. The present review is focused on recent data gained by exploring the anatomy, pathophysiology, classification, theories explaining the development of haemorrhoids, as well as aetiological invasive and surgical treatment modalities.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalProceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences
Volume75
Issue number1
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • Anal canal
  • Anatomy
  • Classification of haemorrhoidal disease
  • Invasive treatment
  • Pathophysiology

Field of Science

  • 3.1 Basic medicine
  • 3.2 Clinical medicine

Publication Type

  • 1.4. Reviewed scientific article published in Latvia or abroad in a scientific journal with an editorial board (including university editions)

Fingerprint Dive into the research topics of 'Worldwide Disease — Haemorrhoids. How much do we know?'. Together they form a unique fingerprint.

Cite this