Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk; Kavil Patel; Nathan  Scott; Craig Richardson; Darragh Murnane; Fang Liu

doi:10.1208/s12249-019-1534-5

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk, Kavil Patel, Nathan Scott, Craig Richardson, Darragh Murnane, Fang Liu (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Suspension of microparticles in an easy-to-swallow liquid is one approach to
develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

Original language	English
Article number	3
Journal	AAPS PharmSciTech
Volume	21
Issue number	3
DOIs	https://doi.org/10.1208/s12249-019-1534-5
Publication status	Published - 2020
Externally published	Yes

Field of Science*

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

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10.1208/s12249-019-1534-5

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abstract = "Suspension of microparticles in an easy-to-swallow liquid is one approach todevelop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size ",

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AU - Patel, Kavil

AU - Scott, Nathan

AU - Richardson, Craig

AU - Murnane, Darragh

AU - Liu, Fang

PY - 2020

Y1 - 2020

N2 - Suspension of microparticles in an easy-to-swallow liquid is one approach todevelop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

AB - Suspension of microparticles in an easy-to-swallow liquid is one approach todevelop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

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U2 - 10.1208/s12249-019-1534-5

DO - 10.1208/s12249-019-1534-5

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Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Abstract

Field of Science*

Publication Type*

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