Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk; Kavil Patel; Nathan  Scott; Craig Richardson; Darragh Murnane; Fang Liu

doi:10.1208/s12249-019-1534-5

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk
, Kavil Patel
, Nathan Scott
, Craig Richardson
, Darragh Murnane
, Fang Liu (Corresponding Author)

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Suspension of microparticles in an easy-to-swallow liquid is one approach to
develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

Original language	English
Article number	3
Journal	AAPS PharmSciTech
Volume	21
Issue number	3
DOIs	https://doi.org/10.1208/s12249-019-1534-5
Publication status	Published - 2020
Externally published	Yes

Field of Science*

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1208/s12249-019-1534-5

Cite this

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title = "Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties",

abstract = "Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size ",

author = "Valentyn Mohylyuk and Kavil Patel and Nathan Scott and Craig Richardson and Darragh Murnane and Fang Liu",

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doi = "10.1208/s12249-019-1534-5",

language = "English",

volume = "21",

journal = "AAPS PharmSciTech",

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T1 - Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

AU - Mohylyuk, Valentyn

AU - Patel, Kavil

AU - Scott, Nathan

AU - Richardson, Craig

AU - Murnane, Darragh

AU - Liu, Fang

PY - 2020

Y1 - 2020

N2 - Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

AB - Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000496490100003

U2 - 10.1208/s12249-019-1534-5

DO - 10.1208/s12249-019-1534-5

M3 - Article

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JO - AAPS PharmSciTech

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ER -

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Abstract

Field of Science*

Publication Type*

Access to Document

Other files and links

Fingerprint

Active Tablet Coating with Amorphous Solid Dispersion of Ibuprofen–HPMCAS from Organic Solution

International Journal of Pharmaceutics (Journal)

Gels (Journal)

Gels (Journal)

Cite this

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Abstract

Field of Science*

Publication Type*

Access to Document

Other files and links

Fingerprint

Research output

Active Tablet Coating with Amorphous Solid Dispersion of Ibuprofen–HPMCAS from Organic Solution

Activities

International Journal of Pharmaceutics (Journal)

Gels (Journal)

Gels (Journal)

Cite this