Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk; Kavil Patel; Nathan  Scott; Craig Richardson; Darragh Murnane; Fang Liu

doi:10.1208/s12249-019-1534-5

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Valentyn Mohylyuk
, Kavil Patel
, Nathan Scott
, Craig Richardson
, Darragh Murnane
, Fang Liu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Suspension of microparticles in an easy-to-swallow liquid is one approach to
develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

Original language	English
Article number	3
Journal	AAPS PharmSciTech
Volume	21
Issue number	3
DOIs	https://doi.org/10.1208/s12249-019-1534-5
Publication status	Published - 2020
Externally published	Yes

Field of Science

3.1 Basic medicine

Publication Type*

1.1. Scientific article indexed in Web of Science and/or Scopus database

Access to Document

10.1208/s12249-019-1534-5

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abstract = "Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size ",

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AU - Mohylyuk, Valentyn

AU - Patel, Kavil

AU - Scott, Nathan

AU - Richardson, Craig

AU - Murnane, Darragh

AU - Liu, Fang

PY - 2020

Y1 - 2020

N2 - Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

AB - Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size

UR - https://www-webofscience-com.db.rsu.lv/wos/alldb/full-record/WOS:000496490100003

U2 - 10.1208/s12249-019-1534-5

DO - 10.1208/s12249-019-1534-5

M3 - Article

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VL - 21

JO - AAPS PharmSciTech

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M1 - 3

ER -

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

Abstract

Field of Science

Publication Type*

Access to Document

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Active Tablet Coating with Amorphous Solid Dispersion of Ibuprofen–HPMCAS from Organic Solution

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